曲安奈德与手术胶水联合应用对大鼠皮肤伤口愈合的药理作用
Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats.
作者信息
Doci Rosana Soares Araújo, Carvalho Filipe Feitosa de, Gomes Rodrigo César, Gianini Reinaldo José, Fanelli Camilla, Noronha Irene de Lourdes, Santos Nelson Brancaccio Dos, Hausen Moema de Alencar, Komatsu Daniel, Randazzo-Moura Priscila
机构信息
Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil.
Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Biomaterials Laboratory - São Paulo (SP) - Brazil.
出版信息
Acta Cir Bras. 2024 Dec 6;39:e399624. doi: 10.1590/acb399624. eCollection 2024.
PURPOSE
The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats.
METHODS
Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.
RESULTS
The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.
CONCLUSION
This association is a powerful and innovative pharmacological tool, promising in translational medicine.
目的
手术胶水广泛用于闭合皮肤外科伤口。皮质类固醇因其抗炎和免疫调节特性而被使用。本研究评估了掺入手术胶（C）中的曲安奈德（AT）对Wistar大鼠伤口愈合初期的药理作用。
方法
通过体内研究，在同一大鼠身上评估了手术胶（C）或手术胶加曲安奈德（C+AT）在术后7天和14天对愈合过程的影响。
结果
C+AT组合未改变聚合物的物理化学性质。这种组合在伤口愈合中证实了皮质类固醇的抗炎和免疫调节作用，新生血管形成和纤维化减少，此外通过肌成纤维细胞平衡和密度较低的胶原纤维进行细胞外基质重塑，最终实现组织再生并可能减少副作用。
结论
这种组合是一种强大且创新的药理工具，在转化医学中有前景。
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