患有自身免疫性风湿疾病的矽肺患者队列中分枝杆菌感染的风险
Risk of mycobacterial infections in a cohort of silicosis patients with autoimmune rheumatic diseases.
作者信息
Mizutani Rafael Futoshi, Santos Ubiratan Paula, Sales Roberta Karla Barbosa, Yuki Emily Figueiredo Neves, Lombardi Elisa Maria Siqueira, Roio Lavinia Clara Del, Terra-Filho Mario
机构信息
. Divisão de Pneumologia, Instituto do Coracao - InCor - Hospital das Clinicas -HCFMUSP - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo (SP) Brasil.
. Divisão de Reumatologia, Hospital das Clinicas -HCFMUSP - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo (SP) Brasil.
出版信息
J Bras Pneumol. 2024 Dec 6;50(5):e20240265. doi: 10.36416/1806-3756/e20240265. eCollection 2024.
OBJECTIVE
To evaluate the incidence rates of mycobacterial infections in silicosis patients with systemic autoimmune rheumatic disease (ARD).
METHODS
This was a retrospective cohort of silicosis patients between January of 1999 and December of 2023. We compared the incidence of tuberculosis and nontuberculous mycobacterial disease (NTM) in patients with silicosis with and without ARD. We also compared the tuberculosis incidence in the overall cohort with general Brazilian population estimates.
RESULTS
The study comprised 369 silicosis patients, of whom 35 (9.5%) had ARD. Having ARD did not affect the cumulative incidence of mycobacterial diseases. The risk of tuberculosis was higher in the cohort when compared with that in the adult Brazilian male population (age-adjusted incidence rate ratio = 20.46; 95% CI 14.89-28.13).
CONCLUSIONS
In this cohort of patients with silicosis, ARD was not associated with the incidence of mycobacterial diseases.
目的
评估合并系统性自身免疫性风湿性疾病（ARD）的矽肺患者分枝杆菌感染的发病率。
方法
这是一项对1999年1月至2023年12月期间矽肺患者的回顾性队列研究。我们比较了合并和未合并ARD的矽肺患者中结核病和非结核分枝杆菌病（NTM）的发病率。我们还将整个队列中的结核病发病率与巴西一般人群的估计发病率进行了比较。
结果
该研究包括369例矽肺患者，其中35例（9.5%）患有ARD。患有ARD并不影响分枝杆菌病的累积发病率。与巴西成年男性人群相比，该队列中结核病的风险更高（年龄调整发病率比=20.46；95%可信区间14.89-28.13）。
结论
在这个矽肺患者队列中，ARD与分枝杆菌病的发病率无关。
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