Wong Y Y, Lichtor T, Brown F D
Surg Neurol. 1985 Feb;23(2):169-72. doi: 10.1016/0090-3019(85)90338-6.
A 67-year-old man developed a sudden onset of severe isolated thrombocytopenia (platelet count, 1000/mm3) after 10 days of phenytoin administration as a prophylactic measure prior to craniotomy. The patient had also been taking cimetidine for 2 months prior to admission. No other hematological complications were noted, and an extensive hematologic investigation was otherwise unremarkable. Rapid resolution of the thrombocytopenia upon discontinuation of phenytoin and cimetidine strongly suggests a drug-induced adverse reaction.
一名67岁男性在开颅手术前作为预防措施服用苯妥英钠10天后，突然出现严重的单纯性血小板减少症（血小板计数为1000/mm³）。患者在入院前2个月还一直在服用西咪替丁。未发现其他血液学并发症，广泛的血液学检查结果无异常。停用苯妥英钠和西咪替丁后血小板减少症迅速缓解，强烈提示药物引起的不良反应。
