一名幼儿的苯妥英钠相关性血小板减少症

Phenytoin-associated thrombocytopenia in a toddler.

作者信息

Alehan F K, Russell E C, Pellock J M

机构信息

Division of Child Neurology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0211, USA.

出版信息

J Child Neurol. 1999 Feb;14(2):130-1. doi: 10.1177/088307389901400212.

DOI:10.1177/088307389901400212

PMID:10073436

Abstract

Hematologic side effects are rare side effects of treatment with phenytoin. We report a 2-year-old girl who developed reversible thrombocytopenia following treatment with phenytoin. Thrombocytopenia as a side effect of phenytoin treatment has usually been reported in adults and generally occurs 2 to 4 weeks after initiation of therapy. In our case, the thrombocytopenia developed on the 11th day of therapy and resolved 5 days after discontinuation of the phenytoin.

摘要

血液学副作用是苯妥英治疗罕见的副作用。我们报告一名2岁女孩，在接受苯妥英治疗后出现可逆性血小板减少症。苯妥英治疗引起的血小板减少症通常在成人中报道，一般在治疗开始后2至4周出现。在我们的病例中，血小板减少症在治疗第11天出现，并在停用苯妥英5天后缓解。