静脉注射免疫球蛋白治疗苯妥英钠所致血小板减少症。
Phenytoin-induced thrombocytopenia treated with intravenous immune globulin.
作者信息
Salzman M B, Smith E M
机构信息
Department of Pediatrics, Kaiser Permanente West Los Angeles Medical Center, CA 90034, USA.
出版信息
J Pediatr Hematol Oncol. 1998 Mar-Apr;20(2):152-3. doi: 10.1097/00043426-199803000-00013.
PURPOSE
To describe the use of intravenous immune globulin (IVIG) in an 8-year-old girl with phenytoin-induced thrombocytopenia and leukopenia.
PATIENTS AND METHODS
An 8-year-old girl had fever, rash, thrombocytopenia, and leukopenia 18 days after initiation of phenytoin therapy. The phenytoin level was elevated. She was treated with 1 g/kg of IVIG.
RESULTS
The thrombocytopenia improved dramatically after IVIG therapy. There was a slower response to the leukopenia.
CONCLUSIONS
Phenytoin hypersensitivity can present with thrombocytopenia and leukopenia. Treatment with IVIG was associated with a rapid rise in the platelet count in the patient in this report. IVIG should be considered for patients with phenytoin-induced thrombocytopenia.
目的
描述静脉注射免疫球蛋白（IVIG）在一名患有苯妥英钠诱导的血小板减少症和白细胞减少症的8岁女孩中的应用。
患者和方法
一名8岁女孩在开始苯妥英钠治疗18天后出现发热、皮疹、血小板减少症和白细胞减少症。苯妥英钠水平升高。她接受了1 g/kg的IVIG治疗。
结果
IVIG治疗后血小板减少症显著改善。白细胞减少症的反应较慢。
结论
苯妥英钠超敏反应可表现为血小板减少症和白细胞减少症。本报告中的患者接受IVIG治疗后血小板计数迅速上升。对于苯妥英钠诱导的血小板减少症患者，应考虑使用IVIG。
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