BGI Research, Hangzhou 310030, China.
BGI Research, Shenzhen 518083, China.
Cell. 2024 Aug 22;187(17):4488-4519. doi: 10.1016/j.cell.2024.07.040.
The completion of the Human Genome Project has provided a foundational blueprint for understanding human life. Nonetheless, understanding the intricate mechanisms through which our genetic blueprint is involved in disease or orchestrates development across temporal and spatial dimensions remains a profound scientific challenge. Recent breakthroughs in cellular omics technologies have paved new pathways for understanding the regulation of genomic elements and the relationship between gene expression, cellular functions, and cell fate determination. The advent of spatial omics technologies, encompassing both imaging and sequencing-based methodologies, has enabled a comprehensive understanding of biological processes from a cellular ecosystem perspective. This review offers an updated overview of how spatial omics has advanced our understanding of the translation of genetic information into cellular heterogeneity and tissue structural organization and their dynamic changes over time. It emphasizes the discovery of various biological phenomena, related to organ functionality, embryogenesis, species evolution, and the pathogenesis of diseases.
人类基因组计划的完成为理解人类生命提供了一个基础蓝图。然而，要理解我们的遗传蓝图如何参与疾病或在时间和空间维度上协调发育的复杂机制，仍然是一个深远的科学挑战。最近细胞组学技术的突破为理解基因组元件的调控以及基因表达、细胞功能和细胞命运决定之间的关系开辟了新的途径。空间组学技术的出现，包括成像和基于测序的方法，使我们能够从细胞生态系统的角度全面理解生物过程。这篇综述介绍了空间组学如何促进我们对遗传信息转化为细胞异质性和组织结构组织以及它们随时间的动态变化的理解。它强调了各种生物学现象的发现，这些现象与器官功能、胚胎发生、物种进化和疾病发病机制有关。
