Dept of Medical Psychology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Joint first authors.
Eur Respir Rev. 2021 Apr 13;30(160). doi: 10.1183/16000617.0298-2020. Print 2021 Jun 30.
Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD.
Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings "COPD" and "Fatigue". Studies were reviewed in accordance with PRISMA guidelines.
196 studies were evaluated. The prevalence of fatigue ranged from 17-95%. Age (r=-0.23 to r=0.27), sex (r=0.11), marital status (r=-0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=-0.55 to r=-0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=-0.78 to r=-0.45), functional capacity (r=-0.77 to r=-0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue.
Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.
疲劳是 COPD 患者的一种痛苦症状。目前对于导致 COPD 患者疲劳的因素知之甚少。本综述总结了目前关于 COPD 患者疲劳的患病率、与疲劳相关的因素以及最常用于评估 COPD 患者疲劳的工具的现有知识。
使用医学主题词“COPD”和“疲劳”，检索了 Pubmed、PsycINFO、EMBASE、Cochrane 和 CINAHL 数据库，从建库到 2020 年 1 月 7 日，检索到了相关研究。按照 PRISMA 指南对研究进行了回顾。
评估了 196 项研究。疲劳的患病率范围为 17-95%。年龄（r=-0.23 至 r=0.27）、性别（r=0.11）、婚姻状况（r=-0.096）、呼吸困难（r=0.13 至 r=0.78）、用力呼气量 1 秒率预测值（r=-0.55 至 r=-0.076）、加重次数（r=0.27 至 r=0.38）、合并症数量（r=0.10）、药物数量（r=0.35）、焦虑（r=0.36 至 r=0.61）、抑郁（r=0.41 至 r=0.66）、肌肉力量（r=-0.78 至 r=-0.45）、功能能力（r=-0.77 至 r=-0.14）和生活质量（r=0.48 至 r=0.77）与疲劳显著相关。
疲劳是 COPD 患者的一种常见症状。多种身体和心理因素似乎与疲劳有关。未来的研究需要在 COPD 患者样本中进行综合分析，以评估这些潜在因素。
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