Wei Ming-Guang, Tian Biao, Xiong Jing-Kang, Feng Juan, Wu Zhen-Tian, Zhang Xi, Zheng Yan-Hua
Medical Center of Hematology, Xinqiao Hospital, Army Medical University, No.83 Xinqiao Road, Chongqing, 400037, China.
Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Ann Hematol. 2024 Dec;103(12):5871-5880. doi: 10.1007/s00277-024-06141-9. Epub 2024 Dec 12.
Primary head and neck lymphoid neoplasms(PHNLN) are described as a series of lymphoid system-derived neoplasms which originally arising from head and neck region. Our study is aimed to present a panoramic view of PHNLN among adolescent and young adult(AYA) patients aged from 15 to 39 years-old. The individual patient information was obtained from Surveillance, Epidemiology and End Results(SEER) database. Male patients outnumbered female patients in most pathological subtypes, with noticeable male predilection observed in Burkitt lymphoma and diffuse large B-cell lymphoma(DLBCL). Classical Hodgkin lymphoma(CHL) accounted for 92.23% of Hodgkin lymphoma. Mature B-cell neoplasms constituted the majority of non-Hodgkin lymphoma(NHL). DLBCL was the most common pathological subtype, followed by follicular lymphoma(FL). Tonsil, salivary glands (especially parotid gland) and nasal cavity were the most three frequent extranodal organs involved. Patients with extranodal involvement exhibited worse prognosis compared to those with lymph node confinement. Patients who suffered from precursor NHL and mature T/NK-cell NHL exhibited prolonged disease-specific survival compared to those with HL, PCN and mature B-cell NHL. AYA patients with absence of other SPM showed dramatic lower risk of death than those with occurrence of SPM. Patients with HL had a favourable survival advantage over those with mature B-cell NHL. Patients with precursor NHL and mature T/NK-cell NHL were at remarkable higher risk of death than those with mature B-cell NHL. Our study elucidated the demographics, distribution of anatomic sites and pathological subtypes, and survival outcomes of PHNLN among AYA population, enhancing comprehension of this rare sort of cancer entities.
原发性头颈部淋巴瘤（PHNLN）被描述为一系列起源于头颈部区域的淋巴系统来源的肿瘤。我们的研究旨在呈现15至39岁青少年和青年（AYA）患者中PHNLN的全景。个体患者信息来自监测、流行病学和最终结果（SEER）数据库。在大多数病理亚型中，男性患者多于女性患者，在伯基特淋巴瘤和弥漫性大B细胞淋巴瘤（DLBCL）中观察到明显的男性偏好。经典霍奇金淋巴瘤（CHL）占霍奇金淋巴瘤的92.23%。成熟B细胞肿瘤构成非霍奇金淋巴瘤（NHL）的大多数。DLBCL是最常见的病理亚型，其次是滤泡性淋巴瘤（FL）。扁桃体、唾液腺（尤其是腮腺）和鼻腔是最常受累的三个结外器官。与局限于淋巴结的患者相比，有结外受累的患者预后更差。与患有HL、PCN和成熟B细胞NHL的患者相比，患有前驱NHL和成熟T/NK细胞NHL的患者疾病特异性生存期延长。没有其他第二原发性恶性肿瘤（SPM）的AYA患者的死亡风险显著低于发生SPM的患者。患有HL的患者比患有成熟B细胞NHL的患者具有更好的生存优势。与患有成熟B细胞NHL 的患者相比，患有前驱NHL和成熟T/NK细胞NHL的患者死亡风险显著更高。我们的研究阐明了AYA人群中PHNLN的人口统计学、解剖部位分布和病理亚型以及生存结果，增强了对这种罕见癌症实体的理解。
