恢复期以及细菌暴露于低于最低抑菌浓度的抗生素环境中。

Recovery period and the exposure of bacteria to subminimal inhibitory concentrations of antibiotics.

作者信息

Kitzis M D, Bouanchaud D H, Acar J F

出版信息

Rev Infect Dis. 1979 Sep-Oct;1(5):825-31. doi: 10.1093/clinids/1.5.825.

DOI:10.1093/clinids/1.5.825

Abstract

The minimal antbiotic concentration (MAC) refers to the lowest concentration of drug that results in a detectable effect on bacteria (e.g., inhibition of growth, change in morphology, and delay in recovery to normal growth in drug-free medium). Strains of Escherichia coli and Staphylococcus aureus were subjected to a range of subminimal inhibitory concentrations of four drugs-ampicillin, gentamicin, rosaramicin, and tetracycline. Inhibition curves (percentage of normal growth vs. concentration of drug) were related to the period of recovery before resumption of normal growth, which was chosen to express MAC value. In both E. coli and S. aureus, the longest delay in recovery of normal growth was observed with rosaramicin. Ampicillin resulted in a delay in recovery only with S. aureus.

摘要

最低抗生素浓度（MAC）是指对细菌产生可检测效应（如抑制生长、形态改变以及在无药物培养基中恢复正常生长的延迟）的最低药物浓度。将大肠杆菌和金黄色葡萄球菌菌株暴露于四种药物（氨苄青霉素、庆大霉素、玫瑰雷米星和四环素）的一系列亚最低抑菌浓度下。抑制曲线（正常生长百分比与药物浓度）与恢复正常生长前的恢复时间相关，选择该时间来表示MAC值。在大肠杆菌和金黄色葡萄球菌中，玫瑰雷米星导致正常生长恢复的延迟最长。氨苄青霉素仅在金黄色葡萄球菌中导致恢复延迟。