Kuniyoshi Yasutaka, Tsujimoto Yasushi, Banno Masahiro, Taito Shunsuke, Ariie Takashi, Kimoto Takeru
Department of Social Services and Healthcare Management, International University of Health and Welfare, Otawara, Tochigi, Japan.
Systematic Review Workshop Peer Support Group (SRWS-PSG), Osaka, Japan.
Obes Rev. 2025 Mar;26(3):e13862. doi: 10.1111/obr.13862. Epub 2024 Dec 11.
The relationship between obesity, metabolic syndrome, related disorders, and various allergic diseases remains unclear. An overview of reviews investigating potential associations between obesity or metabolic syndrome and various allergic diseases was conducted. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Systematic reviews and meta-analyses with summary effect size and corresponding 95% confidence intervals for at least one outcome (asthma, atopic dermatitis, and various allergic diseases) were included. This study encompassed 17 systematic review articles and 29 eligible meta-analyses. All included meta-analyses indicated a positive association between obesity/overweight and asthma. Three meta-analyses from one review demonstrated a positive association between obesity/overweight and the risk of atopic dermatitis. However, no meta-analyses focused on the associations between obesity/overweight or metabolic syndrome and allergic rhinitis, allergic conjunctivitis, or other allergic conditions. All included reviews employed poor methodology according to the AMSTAR-2 assessment tools. Our findings suggest that obesity likely increases the risk of asthma. However, evidence for associations with other allergic diseases is limited. Furthermore, no meta-analyses were conducted to assess the relationship between metabolic syndrome and allergic diseases. Further studies are necessary to elucidate the associations between obesity and the full spectrum of allergic diseases.
肥胖、代谢综合征、相关疾病与各种过敏性疾病之间的关系仍不明确。我们对调查肥胖或代谢综合征与各种过敏性疾病之间潜在关联的综述进行了概述。检索了MEDLINE、EMBASE和Cochrane对照试验中央注册库。纳入了对至少一项结局（哮喘、特应性皮炎和各种过敏性疾病）具有汇总效应量及相应95%置信区间的系统评价和荟萃分析。本研究涵盖17篇系统评价文章和29项符合条件的荟萃分析。所有纳入的荟萃分析均表明肥胖/超重与哮喘之间存在正相关。一项综述中的三项荟萃分析表明肥胖/超重与特应性皮炎风险之间存在正相关。然而，没有荟萃分析关注肥胖/超重或代谢综合征与过敏性鼻炎、过敏性结膜炎或其他过敏状况之间的关联。根据AMSTAR - 2评估工具，所有纳入的综述采用的方法均较差。我们的研究结果表明肥胖可能会增加哮喘风险。然而，与其他过敏性疾病关联的证据有限。此外，没有进行荟萃分析来评估代谢综合征与过敏性疾病之间的关系。有必要进一步开展研究以阐明肥胖与全谱过敏性疾病之间的关联。
