Utkan Korun Zeynep Ece, Yücetürk Ayşen, Karaosmanoğlu Özge, Yıldırım Köpük Şule, Yazıcıoğlu Çağlar, Çakıroğlu Yiğit, Tıraş Bülent
Yeditepe University Kozyatağı Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
Acıbadem Maslak Hospital Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Turk J Obstet Gynecol. 2024 Dec 12;21(4):266-272. doi: 10.4274/tjod.galenos.2024.71091.
Cessation of gonadotropin stimulation might affect follicular growth in patients in POSEIDON groups 3 and 4, which are unresponsive to high-dose stimulation.
In this retrospective study, data were extracted from the medical records of patients treated at the Acıbadem Maslak Hospital Assisted Reproductive Technologies Unit between November 2010 and December 2020. Eighty-five patients who fulfilled the inclusion criteria were included in the study. Gonadotropin stimulation was discontinued if the follicle diameter increased by 2 mm within 7 days after the initiation of stimulation in patients in groups 3 and 4. The outcomes of the treatment strategy and pregnancy were recorded.
Follicular growth was observed in 40% (34/85) of patients, of whom 52.9% (18/34) had 2pn embryos. Ten of the 85 patients (11.8%) underwent embryo transfer, resulting in biochemical pregnancy for two patients and healthy live birth for one patient.
When high-dose stimulation is ineffective, discontinuing gonadotropin administration during ovarian stimulation may provide patients with the opportunity to conceive using their own biological oocytes. To the best of our knowledge, this is the first study to report a live birth rate using this strategy.
停止促性腺激素刺激可能会影响波塞冬分类系统3组和4组中对高剂量刺激无反应的患者的卵泡生长。
在这项回顾性研究中，数据取自2010年11月至2020年12月在阿西巴德姆马斯拉克医院辅助生殖技术科接受治疗的患者的病历。85名符合纳入标准的患者被纳入研究。对于3组和4组患者，如果在刺激开始后7天内卵泡直径增加2毫米，则停止促性腺激素刺激。记录治疗策略的结果和妊娠情况。
40%（34/85）的患者观察到卵泡生长，其中52.9%（18/34）有2PN胚胎。85名患者中有10名（11.8%）进行了胚胎移植，2名患者生化妊娠，1名患者健康活产。
当高剂量刺激无效时，在卵巢刺激期间停止促性腺激素给药可能为患者提供使用自身生物卵子受孕的机会。据我们所知，这是第一项报告使用该策略的活产率的研究。
