Sokol R J, Balistreri W F, Hoofnagle J H, Jones E A
Am J Clin Nutr. 1985 Jan;41(1):66-72. doi: 10.1093/ajcn/41.1.66.
In order to determine the frequency of vitamin E deficiency in adults with chronic liver disease, we measured serum vitamin E concentrations and calculated the ratio of serum vitamin E to total serum lipids (E/lipids) in forty-two patients with primary biliary cirrhosis (PBC) (Group A), fifteen patients with other forms of chronic liver disease (Group B), and twenty-five healthy adult control subjects (Group C). Although the mean serum vitamin E concentration did not differ significantly among the three groups, the ratio of serum vitamin E/lipids was significantly lower in Group A than Groups B and C. Vitamin E deficiency, as defined by the ratio of serum vitamin E/lipids below 0.8 mg/gm, was present in seven (17%) Group A and one (7%) Group B patients. Serum cholylglycine, sulfated lithocholate conjugates, and bilirubin were significantly higher and the mean duration of symptomatic primary biliary cirrhosis was significantly longer (6.6 vs 2.3 years) in the vitamin E-deficient compared to the vitamin E-sufficient Group A patients. Our study demonstrates that vitamin E deficiency may occur in adults with severe, prolonged cholestatic liver disease.
为了确定慢性肝病成人患者中维生素E缺乏症的发生率，我们测定了42例原发性胆汁性肝硬化（PBC）患者（A组）、15例其他形式慢性肝病患者（B组）和25名健康成人对照者（C组）的血清维生素E浓度，并计算了血清维生素E与总血清脂质的比值（E/脂质）。虽然三组的平均血清维生素E浓度无显著差异，但A组血清维生素E/脂质比值显著低于B组和C组。以血清维生素E/脂质比值低于0.8mg/gm定义的维生素E缺乏症，在7例（17%）A组患者和1例（7%）B组患者中存在。与维生素E充足的A组患者相比，维生素E缺乏的A组患者血清胆酰甘氨酸、硫酸化石胆酸结合物和胆红素显著升高，且有症状的原发性胆汁性肝硬化的平均病程显著更长（6.6年对2.3年）。我们的研究表明，严重、长期胆汁淤积性肝病成人患者可能发生维生素E缺乏症。
