Van Gossum A, Nève J
Department of Gastroenterology, Erasme Hospital, Free University of Brussels, Belgium.
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):201-7. doi: 10.1007/BF02790118.
The relationship among impaired selenium status, lipid peroxidation, and liver function was examined in 19 hospitalized patients with severe alcoholic cirrhosis. Plasma selenium was found to be significantly lower (mean +/- SD: 54 +/- 13 micrograms/L) than in healthy controls (83 +/- 11 micrograms/L) and plasma malondialdehyde, assessed as thiobarbituric acid reactants, which reflects lipid peroxidation, was increased (2.0 +/- 1.2 mumol/L vs < 1.2 mumol/L in controls). The mean 14C aminopyrine breath test, an indicator of liver function, was lower than normal (2.7 +/- 1.9 vs 6.3 +/- 0.9% in controls) and found to be significantly correlated with plasma selenium (r = 0.59, p < 0.05). A prospective, randomized selenium supplementation trial was conducted in a group of 16 patients who received either daily 100 micrograms selenium as enriched yeast during 4 mo or a placebo. Among the 10 patients who completed the study, plasma selenium significantly increased in the supplemented group (n = 4; before: 58 +/- 10 micrograms/L, and after 101 +/- 12 micrograms/L, p < 0.01) contrary to the placebo group (n = 6, before: 47 +/- 10 micrograms/L, after: 57 +/- 9 micrograms/L, n.s.). 14C aminopyrine breath test improved in three out of four selenium-supplemented patients and in three out of six placebo patients, but the small number of patients did not allow statistical evaluation. These results demonstrate that low selenium status in alcoholic cirrhosis is correlated to liver function and could be improved by supplementation.
对19例重症酒精性肝硬化住院患者体内硒状态受损、脂质过氧化和肝功能之间的关系进行了研究。发现这些患者的血浆硒水平（均值±标准差：54±13微克/升）显著低于健康对照组（83±11微克/升），而作为反映脂质过氧化的指标，经硫代巴比妥酸反应物评估的血浆丙二醛水平升高（2.0±1.2微摩尔/升，而对照组<1.2微摩尔/升）。作为肝功能指标的平均14C氨基比林呼气试验低于正常水平（2.7±1.9，而对照组为6.3±0.9%），且发现其与血浆硒显著相关（r = 0.59，p<0.05）。对一组16例患者进行了一项前瞻性随机硒补充试验，这些患者在4个月内每日接受100微克作为富硒酵母的硒或安慰剂。在完成研究的10例患者中，补充组（n = 4）的血浆硒显著升高（之前：58±10微克/升，之后：101±12微克/升，p<0.01），而安慰剂组（n = 6，之前：47±10微克/升，之后：57±9微克/升，无显著性差异）则不然。在4例补充硒的患者中有3例以及6例安慰剂患者中有3例的14C氨基比林呼气试验有所改善，但患者数量较少，无法进行统计学评估。这些结果表明，酒精性肝硬化患者的低硒状态与肝功能相关，补充硒可能会改善这种状态。
