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一例以持续性溢泪为表现的鼻型NK/T细胞淋巴瘤

A Case of Nasal NK T-Cell Lymphoma Presenting With Persistent Epiphora.

作者信息

Yun Young Bin, Kim Young Gun, Pak Min Gyoung, Kim Sangjun

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Republic of Korea.

Department of Pathology, Dong-A University College of Medicine, Busan, Republic of Korea.

出版信息

J Rhinol. 2022 Nov;29(3):176-181. doi: 10.18787/jr.2022.00415. Epub 2022 Nov 30.

DOI:10.18787/jr.2022.00415
PMID:39664303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11524375/
Abstract

Nasal type natural killer/T-cell lymphoma (NNKTL) is a rare and aggressive subtype of non-Hodgkin lymphoma originating from a natural killer cell or γδ T cell infected by the Epstein-Barr virus. It usually invades the aerodigestive tract and can rapidly destroy the paranasal sinus, hard palate, and central nervous system. NNKTL is often mistaken for benign conditions such as chronic hypertrophic rhinosinusitis or mucosal inflammatory change, as endoscopic findings of NNKTL presenting nasal mucosal hypertrophy are similar to endoscopic findings for these abovementioned benign conditions. Here, the authors report the diagnosis and examination of NNKTL in a 58-year-old male patient who visited our clinic for nasal cavity discomfort after he underwent a dacryocystorhinostomy to treat dacryocystitis.

摘要

鼻型自然杀伤细胞/T细胞淋巴瘤(NNKTL)是一种罕见且侵袭性强的非霍奇金淋巴瘤亚型,起源于感染了爱泼斯坦-巴尔病毒的自然杀伤细胞或γδT细胞。它通常侵犯上呼吸道和消化道,可迅速破坏鼻窦、硬腭及中枢神经系统。NNKTL常被误诊为慢性肥厚性鼻窦炎或黏膜炎症性改变等良性疾病,因为表现为鼻黏膜肥厚的NNKTL的内镜检查结果与上述良性疾病的内镜检查结果相似。在此,作者报告了一名58岁男性患者NNKTL的诊断及检查情况,该患者因患泪囊炎接受泪囊鼻腔吻合术后因鼻腔不适前来我院就诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b455/11524375/7ed62641668d/jr-2022-00415f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b455/11524375/7ed62641668d/jr-2022-00415f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b455/11524375/7ed62641668d/jr-2022-00415f2.jpg

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本文引用的文献

1
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress.结外鼻型自然杀伤/T细胞淋巴瘤:基础科学与临床进展
Front Pediatr. 2019 Apr 16;7:141. doi: 10.3389/fped.2019.00141. eCollection 2019.
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Extranodal natural killer/T cell lymphoma, nasal type in the middle cranial fossa: A case report.颅中窝鼻型结外自然杀伤/T细胞淋巴瘤:一例报告
Medicine (Baltimore). 2018 Aug;97(34):e12028. doi: 10.1097/MD.0000000000012028.
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The diagnosis and management of NK/T-cell lymphomas.NK/T细胞淋巴瘤的诊断与管理
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A phase II prospective study of the "Sandwich" protocol, L-asparaginase, cisplatin, dexamethasone and etoposide chemotherapy combined with concurrent radiation and cisplatin, in newly diagnosed, I/II stage, nasal type, extranodal natural killer/T-cell lymphoma.一项关于“三明治”方案的II期前瞻性研究,即左旋门冬酰胺酶、顺铂、地塞米松和依托泊苷化疗联合同期放疗及顺铂,用于新诊断的I/II期鼻型结外自然杀伤/T细胞淋巴瘤。
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Extranodal natural killer/T-cell lymphoma, nasal type: clinical and computed tomography findings in the head and neck region.结外鼻型自然杀伤/T 细胞淋巴瘤:头颈部的临床和计算机断层扫描表现。
Laryngoscope. 2012 Dec;122(12):2632-9. doi: 10.1002/lary.23531. Epub 2012 Sep 10.
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The diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia.结外NK/T细胞淋巴瘤,鼻型及侵袭性NK细胞白血病的诊断与管理
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Clinicopathological analysis of 501 non-Hodgkin's lymphomas in Korea according to the revised European-American classification of lymphoid neoplasms.根据欧美淋巴肿瘤修订分类对韩国501例非霍奇金淋巴瘤的临床病理分析
Histopathology. 1999 Oct;35(4):345-54. doi: 10.1046/j.1365-2559.1999.00721.x.