Savage R A
Am J Clin Pathol. 1985 Jan;83(1):34-9. doi: 10.1093/ajcp/83.1.34.
A field trial of the medical significance and possible error rate associated with the Coulter S+II lymphocyte percent was performed by comparing 1,500 sequential differentials performed on Geometric Data Hematrak instruments to the results of Coulter volume displacement enumeration of lymphocytes on three S+II instruments. The results of this study indicate that a statistically significant but medically insignificant bias is present between lymphocyte counting technics, that the statistical imprecision of the determination of lymphocytes by the Coulter lymph percent (CLy%) falls within the expected range for statistical inaccuracy of determination of lymphocytes by manual differential technics and that in virtually all cases no medically significant errors would result from accepting the CLy% as indicating the actual numbers of lymphocytes present, as all blood specimens with medically significant abnormalities would have had manual differential and slide review triggered by other abnormalities in the blood count results. The Coulter lymph percent is a useful addition to the other complete blood count parameters.
通过将在Geometric Data Hematrak仪器上进行的1500次连续血细胞分类结果与三台S+II仪器上淋巴细胞的库尔特体积置换计数结果进行比较，对库尔特S+II淋巴细胞百分比的医学意义及可能的错误率进行了一项现场试验。该研究结果表明，淋巴细胞计数技术之间存在统计学上显著但医学上无显著意义的偏差，库尔特淋巴细胞百分比（CLy%）测定的统计不精密度落在手工分类技术测定淋巴细胞统计不准确的预期范围内，并且在几乎所有情况下，将CLy%视为指示实际存在的淋巴细胞数量不会导致医学上显著的误差，因为所有具有医学显著异常的血液标本都会因血细胞计数结果中的其他异常而触发手工分类和玻片复查。库尔特淋巴细胞百分比是全血细胞计数其他参数的一项有用补充。
