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沉默的巨头：mRNA 5-甲基胞嘧啶修饰中的鉴定、效应分子、分子机制、生理和病理功能

The Quiet Giant: Identification, Effectors, Molecular Mechanism, Physiological and Pathological Function in mRNA 5-methylcytosine Modification.

作者信息

Wang Ruyue, Ding Lifeng, Lin Yudong, Luo Wenqin, Xu Zhehao, Li Weilin, Lu Yi, Zhu Ziwei, Lu Zeyi, Li Fan, Mao Xudong, Xia Liqun, Li Gonghui

机构信息

Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.

Department of Urology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China.

出版信息

Int J Biol Sci. 2024 Nov 18;20(15):6241-6254. doi: 10.7150/ijbs.101337. eCollection 2024.

DOI:10.7150/ijbs.101337
PMID:39664561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11628344/
Abstract

5-Methylcytosine (m5C) is a prevalent nucleotide alteration observed in transfer RNA (tRNA) and ribosomal RNA (rRNA), and it is also widely distributed in the transcriptome, serving as one of the internal modifications of messenger RNA (mRNA) in higher eukaryotes. Increasing evidence has substantiated the presence of m5C in mRNA. As research on m5C progresses, there is an initial comprehension of its molecular mechanisms and biological significance in mRNA. This work aims to provide a comprehensive summary of the most recent advancements in the identification and screening, distribution, molecular functions, and biological effects of m5C in mRNA. We outline the current status of research and provide prospects for potential future applications.

摘要

5-甲基胞嘧啶（m5C）是在转运RNA（tRNA）和核糖体RNA（rRNA）中观察到的一种普遍存在的核苷酸修饰，它也广泛分布于转录组中，是高等真核生物中信使RNA（mRNA）的内部修饰之一。越来越多的证据证实了mRNA中存在m5C。随着对m5C研究的进展，人们对其在mRNA中的分子机制和生物学意义有了初步认识。这项工作旨在全面总结mRNA中m5C在鉴定与筛选、分布、分子功能和生物学效应方面的最新进展。我们概述了当前的研究现状，并对未来潜在的应用前景进行了展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/be94e86b050b/ijbsv20p6241g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/660190ec0524/ijbsv20p6241g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/c93a0eba5537/ijbsv20p6241g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/b4292e19dccf/ijbsv20p6241g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/35c1a89a369c/ijbsv20p6241g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/be94e86b050b/ijbsv20p6241g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/660190ec0524/ijbsv20p6241g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/c93a0eba5537/ijbsv20p6241g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/b4292e19dccf/ijbsv20p6241g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/35c1a89a369c/ijbsv20p6241g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/767e/11628344/be94e86b050b/ijbsv20p6241g005.jpg

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Mol Cell. 2024 Aug 8;84(15):2984-3000.e8. doi: 10.1016/j.molcel.2024.06.021. Epub 2024 Jul 12.
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RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation.RNA 5-甲基胞嘧啶调节YBX2依赖性液-液相分离。
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The role of RNA methylation in tumor immunity and its potential in immunotherapy.
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Mol Cancer. 2024 Jun 20;23(1):130. doi: 10.1186/s12943-024-02041-8.
4
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Cancer Lett. 2024 Aug 10;597:217059. doi: 10.1016/j.canlet.2024.217059. Epub 2024 Jun 13.
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9
[Not Available].[不可用]。
Adv Sci (Weinh). 2024 May;11(20):e2302379. doi: 10.1002/advs.202302379. Epub 2024 Apr 2.
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