哺乳动物表观转录组中5-甲基胞嘧啶的特征分析。
Characterizing 5-methylcytosine in the mammalian epitranscriptome.
作者信息
Hussain Shobbir, Aleksic Jelena, Blanco Sandra, Dietmann Sabine, Frye Michaela
出版信息
Genome Biol. 2013 Nov 29;14(11):215. doi: 10.1186/gb4143.
Abstract
The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.
摘要
转录后修饰5-甲基胞嘧啶（m5C）存在于多种编码和非编码RNA中。我们描述了全转录组范围的方法来捕获全局m5C RNA甲基化组。我们还讨论了m5C在RNA中的潜在功能，并将它们与6-甲基腺嘌呤修饰进行比较。
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