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原发性胆囊鳞状细胞癌：病例报告

Primary Squamous Cell Carcinoma of the Gallbladder: Case Report.

作者信息

Dashti Sahar, Garousi Maryam, Mirzaee Elahe, Abdi Navid, Sanei Mastaneh

机构信息

Department of Radiation Oncology, School of Medicine Iran University of Medical Sciences Tehran Iran.

Department of Pathology, School of Medicine Iran University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2024 Dec 10;12(12):e9652. doi: 10.1002/ccr3.9652. eCollection 2024 Dec.

DOI:10.1002/ccr3.9652
PMID:39664735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11631786/
Abstract

Pure gallbladder squamous cell carcinoma is rare. Adenocarcinoma is the foremost malignant pathology of gallbladder cancer. Simultaneously, squamous cell carcinoma accounts for only 1% of malignant gallbladder tumors. They are often advanced at diagnosis and associated with a poor prognosis. The patient was a 37-year-old man diagnosed with poorly differentiated squamous cell carcinoma of the gallbladder. Cholecystectomy, right hemicolectomy, hepatic wedge resection, and regional lymph node dissection were performed, and then he received six courses of adjuvant chemotherapy with the FOLFOX regimen. After 2 months, liver metastasis was diagnosed, and a chemotherapy regimen consisting of gemcitabine, cisplatin, and pembrolizumab was started. After three courses, stable disease was seen. Surgery is the main treatment. There is no consensus about the best adjuvant treatment. The results obtained from this patient might help elucidate the role of adjuvant therapies in treating this rare case report.

摘要

单纯性胆囊鳞状细胞癌很罕见。腺癌是胆囊癌最主要的恶性病理类型。同时，鳞状细胞癌仅占恶性胆囊肿瘤的1%。它们在诊断时往往已处于晚期，且预后较差。该患者为一名37岁男性，被诊断为低分化胆囊鳞状细胞癌。实施了胆囊切除术、右半结肠切除术、肝楔形切除术和区域淋巴结清扫术，随后他接受了六个疗程的FOLFOX方案辅助化疗。2个月后，诊断出肝转移，于是开始使用由吉西他滨、顺铂和帕博利珠单抗组成的化疗方案。三个疗程后，病情稳定。手术是主要治疗方法。关于最佳辅助治疗尚无共识。从该患者获得的结果可能有助于阐明辅助治疗在治疗这一罕见病例中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/be190d4a54f2/CCR3-12-e9652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/03fbab173f93/CCR3-12-e9652-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/f53875524b03/CCR3-12-e9652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/3720b4a68f9c/CCR3-12-e9652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/be190d4a54f2/CCR3-12-e9652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/03fbab173f93/CCR3-12-e9652-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/f53875524b03/CCR3-12-e9652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/3720b4a68f9c/CCR3-12-e9652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeac/11631786/be190d4a54f2/CCR3-12-e9652-g004.jpg

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2
Gallbladder squamous cell carcinoma: An analysis of 1084 cases from the National Cancer Database.胆囊鳞状细胞癌：来自国家癌症数据库的1084例病例分析。
J Surg Oncol. 2020 Sep;122(4):716-722. doi: 10.1002/jso.26066. Epub 2020 Jun 8.
3
Clinicopathological features and survival of gallbladder squamous cell carcinoma: analysis of 121 cases.
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Int J Clin Exp Pathol. 2018 Jul 1;11(7):3208-3221. eCollection 2018.
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