Rosenthal M B, Barnard R J, Rose D P, Inkeles S, Hall J, Pritikin N
Am J Med. 1985 Jan;78(1):23-7. doi: 10.1016/0002-9343(85)90456-5.
Recent studies have implicated elevated levels of serum estradiol in males as the major predisposing factor for myocardial infarction, with serum cholesterol playing a secondary role. The purpose of the present study was to investigate the effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet and daily exercise on levels of serum estradiol, testosterone, and lipids in males. Twenty-one males participating in the Pritikin Longevity Center 26-day residential program volunteered for the study. During the program, serum estradiol levels were significantly reduced from 47.2 +/- 4.6 to 23.8 +/- 2.5 pg/ml (mean +/- SE) whereas serum testosterone levels were unchanged (5.1 +/- 0.3 versus 5.1 +/- 0.2 ng/ml). Total serum cholesterol levels were reduced from 229 +/- 9 to 181 +/- 7 mg/dl whereas triglyceride levels were reduced from 301 +/- 66 to 151 +/- 13 mg/dl. High-density lipoprotein-cholesterol levels fell from 41 +/- 3 to 35 +/- 1 mg/dl whereas the ratio of total cholesterol to high-density lipoprotein-cholesterol was unchanged (5.5 +/- 0.4 versus 5.1 +/- 0.3).
最近的研究表明，男性血清雌二醇水平升高是心肌梗死的主要诱发因素，血清胆固醇起次要作用。本研究的目的是调查高复合碳水化合物、低脂肪、低胆固醇饮食以及日常锻炼对男性血清雌二醇、睾酮和血脂水平的影响。21名参加普里蒂金长寿中心26天住院项目的男性自愿参与了该研究。在项目期间，血清雌二醇水平从47.2±4.6显著降至23.8±2.5 pg/ml（平均值±标准误），而血清睾酮水平未变（5.1±0.3对5.1±0.2 ng/ml）。血清总胆固醇水平从229±9降至181±7 mg/dl，而甘油三酯水平从301±66降至151±13 mg/dl。高密度脂蛋白胆固醇水平从41±3降至35±1 mg/dl，而总胆固醇与高密度脂蛋白胆固醇的比值未变（5.5±0.4对5.1±0.3）。
