Jabbari Negin, Shooshtari Zahra, Mohammadi Shabnam, Ghazi Narges, Kazemian Mozhgan
Student Research Committee, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.
Dental Research Center, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.
World J Plast Surg. 2024;13(3):49-56. doi: 10.61186/wjps.13.3.49.
We aimed to determine whether collagen membrane coverage in maxillary sinus floor elevation surgery, provides an advantage regarding bone regeneration.
This randomized clinical trial included all healthy adults presented for dental implant placement in the posterior edentulous maxilla at the Maxillofacial Surgery Department of Mashhad Dental School, Mashhad, Iran from 2021-2022. Participants were candidates for sinus floor elevation surgery. Patients were randomly allocated to control (with membrane) and test (without membrane) groups. Surgery was performed through the lateral window technique and using allograft particles. According to the assigned study group; either a collagen membrane was placed over the osteotomy window or it was left uncovered. Six months after surgery when patients were recalled for implant placement, a bone specimen was obtained and sent for histologic and histomorphometric analysis. The predictor variable was the use of collagenous membrane and the outcome variables were the amount of newly formed bone, native bone, and connective tissue.
A total of 30 consecutive patients, with a mean age of 46.33±7.25 years completed the study. Histomorphometric measurements, six months after augmentation revealed that the mean area of connective tissue was significantly less in the group with membrane coverage (P=0.015). The area of newly formed bone was significantly greater in sites covered with a collagen membrane compared to grafted but uncovered sites; (P <0.001).
Covering the lateral osteotomy window with a bioabsorbable collagenous membrane is able to significantly enhance vital bone formation and decrease connective tissue proliferation.
我们旨在确定在上颌窦底提升手术中使用胶原膜是否对骨再生具有优势。
这项随机临床试验纳入了2021年至2022年期间在伊朗马什哈德牙科学校颌面外科就诊、拟在无牙上颌后部植入牙种植体的所有健康成年人。参与者均为上颌窦底提升手术的候选者。患者被随机分为对照组（使用膜）和试验组（不使用膜）。手术通过侧窗技术进行，并使用同种异体骨颗粒。根据指定的研究组，要么在截骨窗上放置胶原膜，要么不覆盖。术后六个月，当患者被召回进行种植体植入时，获取骨标本并送去进行组织学和组织形态计量学分析。预测变量是胶原膜的使用，结果变量是新形成骨、天然骨和结缔组织的量。
共有30例连续患者完成了研究，平均年龄为46.33±7.25岁。增高术后六个月的组织形态计量学测量显示，有膜覆盖组的结缔组织平均面积显著更小（P = 0.015）。与移植但未覆盖的部位相比，胶原膜覆盖部位的新形成骨面积显著更大（P < 0.001）。
用可生物吸收的胶原膜覆盖外侧截骨窗能够显著增强活性骨形成并减少结缔组织增殖。
