Cho Yi-Tzu, Su Hung, Wu Ching-Ying, Jeng Jingyueh, Lee Chi-Wei, Wu Deng-Chyang, Huang Tiao-Lai, Shiea Jentaie
Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, Kaohsiung 807634, Taiwan.
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan.
J Food Drug Anal. 2022 Jun 15;30(2):303-315. doi: 10.38212/2224-6614.3413.
We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient's skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.
我们旨在开发一种高效且非侵入性的策略，用于通过人体皮肤监测药物及其代谢物。将探针采样与热脱附-电喷雾电离串联质谱法（TD-ESI/MS/MS）相结合，以表征痕量特比萘芬，它是患者口服特比萘芬片后分泌在皮肤上的。在从不同皮肤区域采集的样本中直接检测到了特比萘芬离子信号，并对这些信号进行了8周的监测。通过皮肤检测和定位特比萘芬表明，这些方法有助于快速、非侵入性地收集摄入药物在皮肤上的分子信息，用于药代动力学研究。
