Ashley S W, Sonnenschein L A, Cheung L Y
Am J Surg. 1985 Jan;149(1):53-9. doi: 10.1016/s0002-9610(85)80009-x.
Focal gastric mucosal blood flow as measured by the hydrogen gas clearance method was compared with total gastric blood flow as determined by venous outflow in an isolated segment of canine stomach before, during, and after exposure to aspirin. Despite an increase in total gastric blood flow from 10.8 +/- 1.6 ml/min per chamber to 17.4 +/- 1.9 ml/min per chamber and mucosal blood flow at nonulcerated sites from 29.5 +/- 4.3 ml/min per 100 g to 83 +/- 14.4 ml/min per 100 g, mucosal blood flow at the site of aspirin-induced ulceration was significantly reduced from 29.5 +/- 4.3 ml/min per 100 g to 12.5 +/- 2.5 ml/min per 100 g. After the removal of aspirin, mucosal blood flow returned to control levels. Such a redistribution of mucosal blood flow in response to aspirin is consistent with the localized nature of acute aspirin-induced injury. The findings also explain the inability of previous methods measuring blood flow of the entire stomach to demonstrate mucosal ischemia during such injury.
在犬胃的离体节段中，在暴露于阿司匹林之前、期间和之后，通过氢气清除法测量的局灶性胃黏膜血流量与通过静脉流出量测定的总胃血流量进行了比较。尽管总胃血流量从每腔10.8±1.6毫升/分钟增加到每腔17.4±1.9毫升/分钟，未溃疡部位的黏膜血流量从每100克29.5±4.3毫升/分钟增加到每100克83±14.4毫升/分钟，但阿司匹林诱导溃疡部位的黏膜血流量从每100克29.5±4.3毫升/分钟显著降低到每100克12.5±2.5毫升/分钟。去除阿司匹林后，黏膜血流量恢复到对照水平。这种对阿司匹林的黏膜血流量重新分布与急性阿司匹林诱导损伤的局部性质一致。这些发现也解释了以前测量整个胃血流量的方法在这种损伤期间无法显示黏膜缺血的原因。
