Gomez Christian J, Naeem Muhammad, Bechel Meagan A, Battle Wilson, Amin Sagar, Hamid Aws, Berkowitz Eugene, Veeraraghavan Srihari, Filev Peter
From the Department of Radiology and Imaging Sciences, Division of Cardiothoracic Imaging (C.J.G., M.N., M.A.B., W.B., S.A., A.H., E.B., P.F.); and Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine (S.V.), Emory University School of Medicine, Emory University Hospital, 1365 Clifton Rd NE, Ste AT-500, Atlanta, GA 30322.
Radiographics. 2025 Jan;45(1):e240114. doi: 10.1148/rg.240114.
Systemic lupus erythematosus (SLE), commonly referred to as lupus, is a widely prevalent chronic autoimmune disease that can affect any organ system in the body. Although the pathogenesis of this disease is rather complex and poorly understood, ultimately there is an overproduction of multiple self-reactive antinuclear antibodies. These autoantibodies are one of the laboratory hallmarks of the diagnosis and disease activity of SLE. Lupus has a myriad of symptoms and imaging manifestations. Serositis, one of the most common manifestations of the disease, usually occurs with pleural or pericardial effusion with or without associated serosal inflammatory changes. The pulmonary manifestations are heterogeneous, with mostly acute (eg, diffuse alveolar hemorrhage, acute lupus pneumonitis) and some chronic (eg, fibrosing interstitial lung disease, shrinking lung syndrome) lung findings. Cardiac and vascular manifestations include myocarditis; coronary artery disease, including accelerated atherosclerosis; myocardial infarction; and spontaneous dissections, along with vasculitis, aneurysms, Libman-Sacks endocarditis, and arterial and venous thromboembolism. Although patient history and risk factor assessment have a vital role in diagnosing lupus, familiarity with the imaging manifestations aids radiologists in optimizing patient care, assessing for complications, and uncovering undiagnosed cases of lupus. This fact emphasizes the importance of recognizing the complex multisystem involvement of lupus seen at imaging. In this article, the authors review the thoracic and cardiovascular imaging manifestations of lupus. RSNA, 2024.
系统性红斑狼疮（SLE），通常简称为狼疮，是一种广泛流行的慢性自身免疫性疾病，可影响身体的任何器官系统。尽管这种疾病的发病机制相当复杂且了解甚少，但最终会产生多种自身反应性抗核抗体。这些自身抗体是SLE诊断和疾病活动的实验室标志之一。狼疮有无数的症状和影像学表现。浆膜炎是该疾病最常见的表现之一，通常伴有胸膜或心包积液，伴有或不伴有相关的浆膜炎症改变。肺部表现多种多样，主要为急性（如弥漫性肺泡出血、急性狼疮性肺炎）和一些慢性（如纤维化间质性肺病、肺萎陷综合征）肺部表现。心脏和血管表现包括心肌炎；冠状动脉疾病，包括加速动脉粥样硬化；心肌梗死；以及自发性夹层，还有血管炎、动脉瘤、Libman-Sacks心内膜炎以及动脉和静脉血栓栓塞。虽然患者病史和危险因素评估在狼疮诊断中起着至关重要的作用，但熟悉影像学表现有助于放射科医生优化患者护理、评估并发症以及发现未确诊的狼疮病例。这一事实强调了认识到影像学上所见狼疮复杂的多系统受累情况的重要性。在本文中，作者回顾了狼疮的胸部和心血管影像学表现。RSNA，2024年
