Grodin W K, Epstein M A, Epstein R A
Anesthesiology. 1985 Jan;62(1):60-4. doi: 10.1097/00000542-198501000-00012.
The authors demonstrated that soda lime will adsorb enflurane or isoflurane as a function of the water content of the soda lime. Various volumes of liquid enflurane or isoflurane were placed in an equilibration flask containing fresh (15% water by weight) or dried soda lime and the vapor phase anesthetic concentrations plotted. When dry soda lime was used, the plot of concentration as a function of volume of liquid added was biphasic: initially flat and then rising linearly. This is qualitatively similar to data reported previously for halothane. The authors hypothesize that drying soda lime produces a molecular sieve-like structure, as adsorption is greatest for molecules with small carbon chain lengths and kinetic diameters, or with structural characteristics such as cis/trans isomerism, which effectively reduce molecular size.
作者证明,碱石灰会根据碱石灰的含水量吸附安氟醚或异氟醚。将不同体积的液态安氟醚或异氟醚置于装有新鲜的(重量含水量为15%)或干燥碱石灰的平衡烧瓶中,并绘制气相麻醉剂浓度曲线。当使用干燥的碱石灰时,浓度随添加的液体体积变化的曲线呈双相:最初是平的,然后呈线性上升。这在定性上与先前报道的氟烷数据相似。作者推测,干燥的碱石灰会产生类似分子筛的结构,因为对于碳链长度短、动力学直径小或具有顺式/反式异构等结构特征(能有效减小分子大小)的分子,吸附作用最强。