Weinstein A G, Cuskey W
Ann Allergy. 1985 Jan;54(1):19-24.
Thirty-nine chronic asthmatic children were enrolled in a 6-month outpatient theophylline compliance study. Seventy-two percent of these patients maintained mean theophylline levels greater than or equal to 5 mcg/ml, the definition of theophylline compliance. Both compliant and noncompliant patients showed significant reduction in wheezing symptoms (P less than .005). Demographic factors including age, race, sex, and number of parents at home were not correlated with drug compliance behavior. Specific behavioral interventions were implemented to promote drug compliance. Behavioral interventions that were most effective in achieving compliance were parental encouragement and increasing parental supervision of medication (compliance, asthma, theophylline, behavioral intervention).
39名慢性哮喘儿童参与了一项为期6个月的门诊茶碱依从性研究。这些患者中有72%的人维持的平均茶碱水平大于或等于5微克/毫升，这是茶碱依从性的定义。依从和不依从的患者喘息症状均有显著减轻（P<0.005）。包括年龄、种族、性别和家中父母数量在内的人口统计学因素与药物依从行为无关。实施了特定的行为干预措施以促进药物依从性。在实现依从性方面最有效的行为干预措施是父母的鼓励以及加强父母对用药的监督（依从性、哮喘、茶碱、行为干预）。
