Sublett J L, Pollard S J, Kadlec G J, Karibo J M
Ann Allergy. 1979 Aug;43(2):95-7.
Sub-therapeutic theophylline levels due to patient (parent) non-compliance is a significant cause of outpatient treatment failure in childhood asthma. In a study of 50 known asthmatic children with acute asthmatic episodes, 98% had sub-therapeutic theophylline levels less than 10 mcg/ml with 75.5% due to inadequate patient (parent) compliance.
由于患者(家长)不依从导致茶碱水平低于治疗剂量是儿童哮喘门诊治疗失败的一个重要原因。在一项对50名已知患有哮喘且有急性哮喘发作的儿童的研究中,98%的儿童茶碱水平低于治疗剂量,即低于10微克/毫升,其中75.5%是由于患者(家长)依从性不足所致。