Hu Qing, Liao Hua, Yu Haiyan
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Public Health. 2025 Jan;238:162-172. doi: 10.1016/j.puhe.2024.10.029. Epub 2024 Dec 12.
Addressing the research gap on neonatal preterm birth's global impact, this study aims to present a detailed analysis of its incidence and mortality rates from 1990 to 2019, capturing the disease burden's evolution during this timeframe.
We analyzed Global Burden of Disease Study 2019 data across 204 countries to assess age-standardized incidence, prevalence, mortality, and DALYs for neonatal preterm birth from 1990 to 2019, along with EPAC and risk factors.
From 1990 to 2019, EPAC for neonatal death at 0-6 days was -1.75 %, and DALYs was -1.75 %. For deaths under 5 years, EPAC was -2.23 %, and DALYs was -2.19 %. Key risk factors for neonatal preterm birth DALYs included low birth weight, gestational age, ambient air pollution, and household pollution from solid fuels.
Preterm birth notably increases neonatal risks at 0-6 days and under 5 years. Our study shows diseased disease burdens in these periods. Preventive strategies, such as reducing household and ambient air pollution, are crucial for preterm birth reduction. Tailored regional interventions are essential.
为填补关于新生儿早产全球影响的研究空白，本研究旨在详细分析1990年至2019年期间其发病率和死亡率，了解该时间段内疾病负担的演变情况。
我们分析了204个国家的《2019年全球疾病负担研究》数据，以评估1990年至2019年期间新生儿早产的年龄标准化发病率、患病率、死亡率和伤残调整生命年，以及早期早产并发症（EPAC）和风险因素。
1990年至2019年期间，0至6天新生儿死亡的早期早产并发症为-1.75%，伤残调整生命年为-1.75%。5岁以下儿童死亡的早期早产并发症为-2.23%，伤残调整生命年为-2.19%。新生儿早产伤残调整生命年的主要风险因素包括低出生体重、胎龄、环境空气污染和固体燃料造成的家庭污染。
早产显著增加了0至6天和5岁以下儿童的新生儿风险。我们的研究显示了这些时期的疾病负担。减少家庭和环境空气污染等预防策略对于减少早产至关重要。量身定制的区域干预措施必不可少。
