Vahed Neda, Saberizafarghandi Mohammad Bagher, Bashirpour Hamed, Ahmadkhaniha Hamid Reza, Arezoomandan Reza
Research Center for Addiction and Risky Behaviors (ReCARB), Iran University of Medical Sciences, Tehran, Iran.
Department of Addiction, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran.
J Clin Neurosci. 2025 Feb;132:110982. doi: 10.1016/j.jocn.2024.110982. Epub 2024 Dec 11.
Brain function changes as a result of cannabis use. This study examined the brain activity of cannabis users compared to a healthy group and nicotine smokers, focusing on the age of onset, duration of use, and dosage.
Demographic and quantitative electroencephalography (QEEG) data of 15 healthy individuals, 20 patients with chronic cannabis use, and 15 nicotine smokers were collected and recorded during the eyes-closed and eyes-open conditions in the resting state. The data were analyzed using MATLAB software and the EEGLAB toolbox.
In the eyes-closed condition, cannabis users exhibited significantly elevated relative theta band power in widespread brain regions compared to both the healthy group and nicotine smokers. They showed decreased relative power in the beta and gamma bands in the parietal and occipital regions when compared to nicotine smokers. In the eyes-open condition, cannabis users displayed increased relative theta band power in widespread brain regions relative to both groups. Additionally, lower relative power in the beta and gamma bands was observed in cannabis users compared to the healthy group in the frontal region, as well as in various brain regions compared to nicotine smokers. A significant relationship was identified between gamma-band power, age of onset, and dosage of cannabis use.
These findings suggest that cannabis use leads to changes in brain wave patterns during the resting state, which may be linked to cognitive impairments affecting functions. Understanding these associations is essential for developing effective intervention programs aimed at mitigating cognitive deficits related to cannabis use.
使用大麻会导致大脑功能发生变化。本研究比较了大麻使用者与健康组及吸烟者的大脑活动，重点关注发病年龄、使用时长和剂量。
收集并记录了15名健康个体、20名慢性大麻使用者和15名吸烟者在静息状态下闭眼和睁眼时的人口统计学数据及定量脑电图（QEEG）数据。使用MATLAB软件和EEGLAB工具箱对数据进行分析。
在闭眼状态下，与健康组和吸烟者相比，大麻使用者在广泛脑区的相对θ频段功率显著升高。与吸烟者相比，他们在顶叶和枕叶区域的β和γ频段相对功率降低。在睁眼状态下，与两组相比，大麻使用者在广泛脑区的相对θ频段功率增加。此外，与健康组相比，大麻使用者在额叶区域的β和γ频段相对功率较低，与吸烟者相比，在多个脑区也是如此。γ频段功率、发病年龄和大麻使用剂量之间存在显著关系。
这些发现表明，使用大麻会导致静息状态下脑电波模式发生变化，这可能与影响功能的认知障碍有关。了解这些关联对于制定有效的干预计划以减轻与使用大麻相关的认知缺陷至关重要。
