Li Fangyu, Gan Lu, Yang Xurui, Tan Zhongbiao, Shi Hao, Lai Chenhuan, Zhang Daihui
School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, Jiangsu 223003, China.
College of Traditional Chinese Medicine, Xinjaing Medical University, Urumqi, Xinjiang 830017, China.
Int J Biol Macromol. 2025 Jan;287:138643. doi: 10.1016/j.ijbiomac.2024.138643. Epub 2024 Dec 10.
Polymeric hydrogels, characterized by their highly hydrophilic three-dimensional network structures, boast exceptional physical and chemical properties alongside high biocompatibility and biodegradability. These attributes make them indispensable in various biomedical applications such as drug delivery, tissue engineering, wound dressings and sensor technologies. With the integration of artificial intelligence (AI), hydrogels are undergoing significant transformations in design, leveraging human-machine interaction, machine learning, neural networks, and 3D/4D printing technology. This article provides a concise yet comprehensive overview of polysaccharide-based hydrogels, exploring their intrinsic properties, functionalities, preparation techniques, and classifications, alongside their progress in biomedical research. Special emphasis is placed on AI-enhanced hydrogels, underscoring their transformative potential in redefining hydrogel performance and functionality. By integrating AI technologies, these intelligent hydrogels open unprecedented opportunities in precision medicine, adaptive biomaterials, and smart healthcare systems, highlighting promising directions for future research.
聚合物水凝胶以其高度亲水的三维网络结构为特征，除了具有高生物相容性和生物降解性外，还拥有卓越的物理和化学性质。这些特性使其在药物递送、组织工程、伤口敷料和传感器技术等各种生物医学应用中不可或缺。随着人工智能（AI）的融入，水凝胶在设计上正在经历重大变革，利用人机交互、机器学习、神经网络和3D/4D打印技术。本文简要而全面地概述了基于多糖的水凝胶，探讨了它们的内在性质、功能、制备技术和分类，以及它们在生物医学研究中的进展。特别强调了人工智能增强的水凝胶，强调了它们在重新定义水凝胶性能和功能方面的变革潜力。通过整合人工智能技术，这些智能水凝胶在精准医学、适应性生物材料和智能医疗系统中开启了前所未有的机遇，突出了未来研究的有前景的方向。
