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基于海藻酸盐的水凝胶在生物医学中的应用:综述。

Alginate-based hydrogels mediated biomedical applications: A review.

机构信息

School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

出版信息

Int J Biol Macromol. 2024 Nov;279(Pt 1):135019. doi: 10.1016/j.ijbiomac.2024.135019. Epub 2024 Aug 28.

Abstract

With the development in the field of biomaterials, research on alternative biocompatible materials has been initiated, and alginate in polysaccharides has become one of the research hotspots due to its advantages of biocompatibility, biodegradability and low cost. In recent years, with the further understanding of microscopic molecular structure and properties of alginate, various physicochemical methods of cross-linking strategies, as well as organic and inorganic materials, have led to the development of different properties of alginate hydrogels for greatly expanded applications. In view of the potential application prospects of alginate-based hydrogels, this paper reviews the properties and preparation of alginate-based hydrogels and their major achievements in delivery carrier, dressings, tissue engineering and other applications are also summarized. In addition, the combination of alginate-based hydrogel and new technology such as 3D printing are also involved, which will contribute to further research and exploration.

摘要

随着生物材料领域的发展,替代生物相容性材料的研究已经启动,而多糖中的藻酸盐由于其生物相容性、可生物降解性和低成本的优势,成为研究热点之一。近年来,随着对藻酸盐微观分子结构和性质的进一步了解,各种物理化学交联策略以及有机和无机材料的应用,导致了具有不同性能的藻酸盐水凝胶的发展,从而极大地扩展了其应用。鉴于藻酸盐基水凝胶的潜在应用前景,本文综述了藻酸盐基水凝胶的性质和制备方法,并总结了其在药物传递载体、敷料、组织工程等方面的主要应用成果。此外,还涉及到藻酸盐基水凝胶与 3D 打印等新技术的结合,这将有助于进一步的研究和探索。

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