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免疫比值在 HIV 中的应用:对监测和治疗策略的影响。

Utilization of immunological ratios in HIV: Implications for monitoring and therapeutic strategies.

机构信息

Department of Medical Laboratory Science, Kampala International University, Kampala, Uganda.

School of Nursing Science, Kampala International University, Kampala, Uganda.

出版信息

Medicine (Baltimore). 2024 Mar 1;103(9):e37354. doi: 10.1097/MD.0000000000037354.

DOI:10.1097/MD.0000000000037354
PMID:38428854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10906605/
Abstract

Human immunodeficiency virus (HIV) infection remains a significant global health concern, necessitating ongoing research and innovation in the quest for improved disease management. Traditional markers for monitoring HIV progression and the effectiveness of antiretroviral therapy have limitations in capturing the intricate immune responses and inflammatory dynamics in people with HIV. In recent years, the concept of inflammation ratios has gained prominence as a valuable tool for assessing and understanding the complex interplay between inflammation, immune function, and HIV. In this abstract, we provide an overview of the emerging field of utilizing inflammation ratios in the context of HIV and its implications for disease monitoring and therapeutic strategies. These ratios, such as the CD4/CD8 ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio, offer a more comprehensive assessment of an individual's immune status and inflammatory state. By exploring the clinical implications of inflammation ratios, including their potential to predict disease complications and guide personalized treatment approaches, this publication sheds light on the potential benefits of incorporating inflammation ratios into routine HIV care. Furthermore, we emphasize the importance of ongoing research in this field to further refine our understanding of the utility and significance of inflammation ratios in improving the lives of people with HIV.

摘要

人类免疫缺陷病毒(HIV)感染仍然是一个重大的全球健康问题,需要不断进行研究和创新,以寻求改善疾病管理的方法。传统的 HIV 进展和抗逆转录病毒治疗效果的监测标志物在捕捉 HIV 感染者复杂的免疫反应和炎症动态方面存在局限性。近年来,炎症比值的概念作为评估和理解炎症、免疫功能和 HIV 之间复杂相互作用的有价值工具而备受关注。在本摘要中,我们概述了在 HIV 背景下利用炎症比值的新兴领域及其对疾病监测和治疗策略的影响。这些比值,如 CD4/CD8 比值、中性粒细胞与淋巴细胞比值和单核细胞与淋巴细胞比值,提供了对个体免疫状态和炎症状态的更全面评估。通过探讨炎症比值的临床意义,包括它们预测疾病并发症和指导个体化治疗方法的潜力,本出版物阐明了将炎症比值纳入常规 HIV 护理中的潜在益处。此外,我们强调了在该领域进行持续研究的重要性,以进一步深化我们对炎症比值在改善 HIV 感染者生活方面的实用性和重要性的理解。