Liu Yu, Li Qian, Cao Gangchi, Wei Huijuan, Xue Chuansong, Liu Jianhao
Sanya Hospital of Traditional Chinese Medicine, Hannan, China.
Department of Medical Oncology, Hangzhou Cancer Hospital, Hangzhou, China.
J Cancer. 2024 Nov 4;15(20):6798-6807. doi: 10.7150/jca.99781. eCollection 2024.
The tumor immune microenvironment is a crucial factor influencing tumor progression, and its molecular mechanisms have become a key topic in immunotherapy research. Programmed death receptor-1 ligand (PD-L1, CD274) is a well-known immunosuppressive molecule that can mediate the immune escape of tumor cells. The aim of this study was to evaluate the significance of PD-L1 in human cancer by integrated bioinformatics analysis. Tumor IMmune Estimation Resource (TIMER), GEPIA, Kaplan-Meier plotter, TISIDB and Tumor Immune Single Cell Hub (TISCH) were used to perform the corresponding analysis. The results showed that PD-L1 was dysregulated in various cancers and was associated with the overall survival of cancer patients, which was associated with macrophage infiltration levels. Moreover, PD-L1 expression showed a significant correlation with macrophages and was universally expressed on tumor-associated macrophages (TAMs). Notably, the expression of PD-L1 on TAMs was found to be correlated with immunotherapy response in certain cancers based on analysis of single-cell RNA sequencing data. In conclusion, PD-L1 plays a significant role in cancer, which may partly be influenced by TAMs.
肿瘤免疫微环境是影响肿瘤进展的关键因素，其分子机制已成为免疫治疗研究的关键课题。程序性死亡受体1配体（PD-L1，CD274）是一种著名的免疫抑制分子，可介导肿瘤细胞的免疫逃逸。本研究旨在通过综合生物信息学分析评估PD-L1在人类癌症中的意义。使用肿瘤免疫估计资源（TIMER）、GEPIA、Kaplan-Meier绘图仪、TISIDB和肿瘤免疫单细胞中心（TISCH）进行相应分析。结果表明，PD-L1在多种癌症中表达失调，与癌症患者的总生存期相关，这与巨噬细胞浸润水平有关。此外，PD-L1表达与巨噬细胞呈显著相关，并在肿瘤相关巨噬细胞（TAM）上普遍表达。值得注意的是，基于单细胞RNA测序数据分析发现，TAM上PD-L1的表达与某些癌症的免疫治疗反应相关。总之，PD-L1在癌症中起重要作用，这可能部分受TAM影响。
