Cortelli P, Sacquegna T, Albani F, Baldrati A, D'Alessandro R, Baruzzi A, Lugaresi E
Arch Neurol. 1985 Jan;42(1):46-8. doi: 10.1001/archneur.1985.04060010052015.
The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17 patients during treatment with oral racemic propranolol hydrochloride in doses of 40 to 240 mg/day. Propranolol decreased the migraine index more than 70% in 13 patients: five patients at a dosage of 40 mg/day, five patients at a dosage of 120 mg/day, and three patients at a dosage of 240 mg/day. Three patients did not achieve a good improvement of migraine at any of the doses used. The relief of migraine was not directly related to the propranolol and 4-hydroxypropranolol plasma concentrations.
