血浆普萘洛尔浓度与特发性震颤缓解之间的关系。
Relationship between plasma propranolol concentration and relief of essential tremor.
作者信息
Jefferson D, Jenner P, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1979 Sep;42(9):831-7. doi: 10.1136/jnnp.42.9.831.
Abstract
The relationship between plasma propranolol concentration and relief of essential tremor was examined in 11 patients during treatment with oral racemic propranolol in doses of 30 to 640 mg/day. Although propranolol decreased tremor in all 11 patients, the degree of improvement varied widely in individuals (mean 51%, range 25--90%), and was not related directly occurred at plasma propranolol concentrations below 20 ng/ml (0.077 mumol/l) and, in three others, below 40 ng/ml (0.154 mumol/l). It is concluded that the optimum response of essential tremor to propranolol is achieved at relatively low plasma propranolol levels, levels which are obtained by daily propranolol doses of 120--240 mg.
摘要
在11例接受口服消旋普萘洛尔治疗（剂量为30至640毫克/天）的患者中，研究了血浆普萘洛尔浓度与特发性震颤缓解之间的关系。尽管普萘洛尔使所有11例患者的震颤减轻，但个体改善程度差异很大（平均51%，范围25%-90%），且与血浆普萘洛尔浓度无直接关系。有8例患者在血浆普萘洛尔浓度低于20纳克/毫升（0.077微摩尔/升）时震颤减轻，另有3例在低于40纳克/毫升（0.154微摩尔/升）时震颤减轻。得出的结论是，特发性震颤对普萘洛尔的最佳反应是在相对较低的血浆普萘洛尔水平时实现的，这些水平可通过每日120至240毫克的普萘洛尔剂量获得。
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