Wong L, Nation R L, Chiou W L, Mehta P K
Br J Clin Pharmacol. 1979 Aug;8(2):163-7. doi: 10.1111/j.1365-2125.1979.tb05815.x.
1 The plasma levels of propranolol and 4-hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4-hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/- s.d.) plasma concentration ratio of 4-hydroxypropranolol to propranolol was 0.130 (+/- 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4-hydroxypropranolol and that of propranolol. 5 Propranolol and 4-hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed.
已对17名接受普萘洛尔长期口服治疗的高血压患者测定了其血浆中普萘洛尔和4-羟基普萘洛尔的水平。
血浆普萘洛尔浓度范围为5.3至300 ng/ml，4-羟基普萘洛尔的浓度范围为2.1至36.0 ng/ml。
4-羟基普萘洛尔与普萘洛尔的平均（±标准差）血浆浓度比为0.130（±0.005）；然而，观察到个体值范围非常宽，从0.057至0.241。
观察到4-羟基普萘洛尔的血浆浓度与普萘洛尔的血浆浓度之间存在统计学显著相关性。
普萘洛尔和4-羟基普萘洛尔的血浆浓度各自与每日普萘洛尔剂量显著但相关性较差。
已讨论了结果的临床意义。
