Zeng Zhaohao, Jin Wen, Huang Kunyu, Xiong Lijiao, Luo Yu, Li Guoyang, Zhang Wenli, Hong Guo, Mao Fengju, Xiong Kaifen, Luo Xiaoguang
Department of Neurology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, China.
The Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Front Nutr. 2024 Nov 28;11:1502748. doi: 10.3389/fnut.2024.1502748. eCollection 2024.
Higher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson's disease (PD) where frailty is highly prevalent. This study aimed to investigate the association between composite dietary antioxidant index (CDAI), a composite score reflecting antioxidant vitamin and mineral intakes, and frailty risk in the general United States (US) population and PD patients.
Data from 21,354 participants ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 2003-2018 represented the general population sample, while 268 PD patients were analyzed separately. Frailty was defined using a validated index. Weighted logistic regression and restricted cubic splines (RCS) examined overall and nonlinear CDAI-frailty associations, adjusting for sociodemographics, lifestyle factors, and comorbidities.
In the general population, each unit increase in CDAI was associated with a 3.7% lower likelihood of frailty after full adjustments. Vitamin A, C, E, selenium and carotenoids exhibited J-shaped relationships where frailty risk decreased below intake thresholds of 1093.04 μg, 161.53 mg, 13.66 mg, 109.99 μg, and 5057.50 μg, respectively. In contrast, the CDAI- frailty inverse association was weaker among PD patients and only vitamin C (threshold 52.45 mg) and zinc (9.35 mg) showed nonlinear links.
Higher dietary antioxidant intake was associated with lower frailty prevalence in the general US population, with vitamins A, C, E, selenium, and carotenoids exhibiting nonlinear J-shaped relationships. In contrast, these associations were weaker and less consistent among PD patients, with only vitamins C and zinc showing nonlinear correlations. These findings highlight population-specific differences in the role of dietary antioxidants in frailty and suggest the need for personalized nutritional strategies in PD frailty management.
较高的抗氧化剂摄入量与降低多种慢性疾病的风险相关。然而，复合膳食抗氧化剂与虚弱之间的关系尚未得到明确阐述，尤其是在帕金森病（PD）等神经退行性疾病中，虚弱现象极为普遍。本研究旨在调查复合膳食抗氧化剂指数（CDAI，一种反映抗氧化维生素和矿物质摄入量的综合评分）与美国普通人群及PD患者的虚弱风险之间的关联。
2003 - 2018年美国国家健康与营养检查调查（NHANES）中21354名年龄≥40岁的参与者的数据代表了普通人群样本，同时对268名PD患者进行了单独分析。使用经过验证的指数定义虚弱。加权逻辑回归和受限立方样条（RCS）检验了CDAI与虚弱之间的总体和非线性关联，并对社会人口统计学、生活方式因素和合并症进行了调整。
在普通人群中，完全调整后CDAI每增加一个单位，虚弱的可能性降低3.7%。维生素A、C、E、硒和类胡萝卜素呈现J形关系，即虚弱风险在摄入量分别低于1093.04μg、161.53mg、13.66mg、109.99μg和5057.50μg的阈值时降低。相比之下，PD患者中CDAI与虚弱的负相关较弱，只有维生素C（阈值52.45mg）和锌（9.35mg）显示出非线性联系。
较高的膳食抗氧化剂摄入量与美国普通人群中较低的虚弱患病率相关，维生素A、C、E、硒和类胡萝卜素呈现非线性J形关系。相比之下，这些关联在PD患者中较弱且不太一致，只有维生素C和锌显示出非线性相关性。这些发现突出了膳食抗氧化剂在虚弱中的作用存在人群特异性差异，并表明在PD虚弱管理中需要个性化的营养策略。
