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离散型人类嗜T淋巴细胞病毒1型/严重急性呼吸综合征冠状病毒2型双重感染模型的稳定性

Stability of a discrete HTLV-1/SARS-CoV-2 dual infection model.

作者信息

Alshaikh M A, Aljahdali A K

机构信息

Department of Mathematics, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Department of Mathematics, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia.

出版信息

Heliyon. 2024 Mar 18;10(7):e28178. doi: 10.1016/j.heliyon.2024.e28178. eCollection 2024 Apr 15.

Abstract

Dual infection with a virus that targets the immune system, such as HTLV-1 (human T-cell lymphotropic virus class 1), combined with another virus that affects the respiratory system, such as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), can cause serious disease and even death. Given the significance of better comprehending the dual viral infections' dynamics, researchers have been drawn to mathematical analyses of such models. This work investigates the stability of a discrete HTLV-1/SARS-CoV-2 dual infection model. Our approach involves formulating the discrete model through the discretization of the continuous-time one using NSFD (nonstandard finite difference) method. We demonstrate that the NSFD method preserves essential properties of the solutions, such as positivity and boundedness. Additionally, we determine the fixed points and establish the conditions under which they exist. Furthermore, we analyze the global stability of these fixed points utilizing the Lyapunov technique. To illustrate our analytical findings, we do numerical simulations.

摘要

感染一种攻击免疫系统的病毒,如人类嗜T淋巴细胞病毒1型(HTLV-1),再加上另一种影响呼吸系统的病毒,如严重急性呼吸综合征冠状病毒2(SARS-CoV-2),可能会导致严重疾病甚至死亡。鉴于更好地理解双重病毒感染动态的重要性,研究人员已着手对这类模型进行数学分析。这项工作研究了一个离散的HTLV-1/SARS-CoV-2双重感染模型的稳定性。我们的方法包括通过使用非标准有限差分(NSFD)方法对连续时间模型进行离散化来构建离散模型。我们证明了NSFD方法保留了解的基本性质,如正性和有界性。此外,我们确定了不动点并建立了它们存在的条件。此外,我们利用李雅普诺夫技术分析了这些不动点的全局稳定性。为了说明我们的分析结果,我们进行了数值模拟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb0/11636898/3ccfbf866115/gr001.jpg

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