Philipo Veneranda, Lupindu Athumani Msalale, Nzalawahe Jahashi Saidi
Department of Veterinary Medicine and Public Health, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, P.O. Box 3021, Morogoro, Tanzania.
Department of Academics, Livestock Training Agency, Mpwapwa Campus, P.O. Box 51, Mpwapwa, Dodoma, Tanzania.
Vet Med Int. 2024 Dec 5;2024:5055115. doi: 10.1155/vmi/5055115. eCollection 2024.
Cerebral coenurosis is a significant disease that affects sheep and goats worldwide. Studies conducted in northern and southern Tanzania have determined its magnitude and determinants. However, limited information from other regions of the country hinders the development of comprehensive national control plans. This study was conducted to determine the prevalence, knowledge, risk factors, and molecular identity of in sheep and goats in Mpwapwa District, Tanzania, in order to establish the preliminary status of the disease in the central regions. Data were collected through postmortem examinations of 84 sheep and 295 goat heads for cysts, polymerase chain reaction (PCR) and sequencing for species identification, and a structured questionnaire of 303 small ruminant keepers for knowledge and identification of risk factors. The overall prevalence of cerebral coenurosis in sheep and goats was 13.5% (95% confidence interval (CI) 10.3-17.2). In goats, the prevalence of cerebral coenurosis was comparatively higher 15.9% (95% CI 11.9-20.6) than in sheep 4.8% (95% CI 1.3-11.8) ( = 0.008). Multivariate logistic regression analysis identified the origin of sheep and goats (Chipogoro: odds ratio (OR) = 7.54, 95% CI 1.96-28.97, and Iwondo: OR = 3.90, 95% CI 1.04-14.61) as a risk factor. The average knowledge score among small ruminant keepers on disease detection was 60.7%, on disease infection cycle and control was 10.85%, and on zoonotic potential was 1.39%. Phylogenetic analysis of Cytochrome C oxidase subunit I (CO1) gene partial nucleotide sequences revealed the two distinct clusters of , one from Saudi Arabia in 2021 and another from Egypt in 2018, Peru in 2017, and China in 2016. These findings suggest cerebral coenurosis is locally widespread and highlight the importance of considering animal movement patterns, livestock keeper's knowledge, and good husbandry practices when planning for control measures of cerebral coenurosis.
脑多头蚴病是一种在全球范围内影响绵羊和山羊的重要疾病。在坦桑尼亚北部和南部进行的研究已经确定了其规模和决定因素。然而，该国其他地区的信息有限，这阻碍了全面的国家控制计划的制定。本研究旨在确定坦桑尼亚姆普瓦普瓦区绵羊和山羊中脑多头蚴病的患病率、知识水平、风险因素以及分子特征，以便确定该疾病在中部地区的初步状况。通过对84只绵羊和295只山羊头部进行尸检以检查囊肿、进行聚合酶链反应（PCR）和测序以进行物种鉴定，并对303名小型反刍动物饲养者进行结构化问卷调查以了解疾病知识和识别风险因素来收集数据。绵羊和山羊中脑多头蚴病的总体患病率为13.5%（95%置信区间（CI）10.3 - 17.2）。在山羊中，脑多头蚴病的患病率相对较高，为15.9%（95%CI 11.9 - 20.6），高于绵羊的4.8%（95%CI 1.3 - 11.8）（P = 0.008）。多因素逻辑回归分析确定绵羊和山羊的来源地（奇波戈罗：优势比（OR）= 7.54，95%CI 1.96 - 28.97，以及伊翁多：OR = 3.90，95%CI 1.04 - 14.61）为风险因素。小型反刍动物饲养者在疾病检测方面的平均知识得分率为60.7%，在疾病感染周期和控制方面为10.85%，在人畜共患病潜力方面为1.39%。细胞色素C氧化酶亚基I（CO1）基因部分核苷酸序列的系统发育分析揭示了脑多头蚴的两个不同聚类，一个来自2021年的沙特阿拉伯，另一个来自2018年的埃及、2017年的秘鲁和2016年的中国。这些发现表明脑多头蚴病在当地广泛存在，并突出了在制定脑多头蚴病控制措施时考虑动物移动模式、牲畜饲养者知识和良好饲养管理做法的重要性。
