德国三唑作为用于铜催化的叠氮化物-炔烃环加成反应多样化和化学选择性正交交叉偶联的平台。
Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling.
作者信息
Halford-McGuff John M, Richardson Thomas M, McKay Aidan P, Peschke Frederik, Burley Glenn A, Watson Allan J B
机构信息
EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
出版信息
Beilstein J Org Chem. 2024 Dec 5;20:3198-3204. doi: 10.3762/bjoc.20.265. eCollection 2024.
We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.
我们报道了通过锗基炔烃的铜催化叠氮化物-炔烃环加成反应（CuAAC）合成锗基三唑。该反应通常产率高、官能团耐受性好，且与复杂分子兼容。锗部分的引入使得三唑产物能够进一步多样化，包括使用双功能硼基/锗基物种进行化学选择性过渡金属催化的交叉偶联反应。
Zotero 插件