Dahiya Amit, Schoetz Markus D, Schoenebeck Franziska
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Angew Chem Int Ed Engl. 2023 Oct 23;62(43):e202310380. doi: 10.1002/anie.202310380. Epub 2023 Sep 18.
Reported herein is a fully orthogonal olefination, which involves the site- and E-selective coupling of aryl germanes with alkenes, tolerating otherwise widely employed coupling handles such as aromatic (pseudo)halogens (C-I, C-Br, C-Cl, C-F, C-OTf, C-OSO F), silanes and boronic acid derivatives as well as alternative functionalities. This unprecedented [Ge]-based oxidative Heck coupling proceeds at room temperature with high speed (10 min to 2 hours) and operational simplicity owing to its base-free and air-tolerant features.
本文报道了一种完全正交的烯基化反应，该反应涉及芳基锗烷与烯烃的位点选择性和E选择性偶联，能够兼容其他广泛使用的偶联基团，如芳族（拟）卤化物（C-I、C-Br、C-Cl、C-F、C-OTf、C-OSO₂F）、硅烷和硼酸衍生物以及其他官能团。这种前所未有的基于锗的氧化Heck偶联反应在室温下以高速（10分钟至2小时）进行，并且由于其无碱和耐空气的特性，操作简便。
