Mortazavi Seyed Mojtaba, Khoshnood Saeed, Faraji Reza, Baravati Rezvan Bagheri, Khalili Hakime, Radfar Ali, Jalali Elham, Nezam Nia Maria, Akrami Sousan, Shirani Maryam
Non-Communicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
GMS Hyg Infect Control. 2024 Nov 5;19:Doc57. doi: 10.3205/dgkh000512. eCollection 2024.
Vitamin D is a steroid hormone that protects against viral infections by influencing innate and adaptive immune responses. The effectiveness of vitamin D3 supplementation in COVID-19 is unknown. The study's goal was to elucidate the relationship between blood vitamin D levels and COVID-19 clinical outcomes by examining the effect of a single high dose of vitamin D3 on the length of hospital stay in COVID-19 patients.
The descriptive, retrospective study was performed from March to May 2021 at a referral center for patients with COVID-19, in Bam, Iran. A checklist consisting of demographic variables was used to gather data, and laboratory assessments of serum 25(OH) D were evaluated and documented. The connection between serum vitamin D and patient clinical outcomes was investigated after patients were given a single oral dose of 200,000 IU of vitamin D3.
71 COVID-19 patients were treated. Radiological results did not change substantially amongst individuals with various levels of 25(OH)D. After a single dosage of vitamin D3, mean blood levels of 25-hydroxyvitamin D increased considerably and the need for intubation and SpO decreased, and as did the respiratory rate in patients requiring hospitalization due to COVID-19.
A single administration of 200,000 IU of vitamin D3 significantly reduced the severity of COVID-19.
维生素D是一种类固醇激素，可通过影响先天性和适应性免疫反应来预防病毒感染。补充维生素D3对2019冠状病毒病（COVID-19）的有效性尚不清楚。该研究的目的是通过研究单次高剂量维生素D3对COVID-19患者住院时间的影响，阐明血液维生素D水平与COVID-19临床结局之间的关系。
2021年3月至5月，在伊朗巴姆的一家COVID-19患者转诊中心进行了这项描述性回顾性研究。使用包含人口统计学变量的清单收集数据，并对血清25(OH)D进行实验室评估并记录。在患者单次口服200,000 IU维生素D3后，研究血清维生素D与患者临床结局之间的关系。
71例COVID-19患者接受了治疗。不同25(OH)D水平的个体之间，影像学结果没有显著变化。单次服用维生素D3后，25-羟基维生素D的平均血液水平显著升高，插管需求和血氧饱和度（SpO）降低，因COVID-19住院的患者呼吸频率也降低。
单次服用200,000 IU维生素D3可显著降低COVID-19的严重程度。
