培养的库普弗细胞的细胞抑制活性。
The cytostatic activity of cultured Kupffer cells.
作者信息
Pulford K, Souhami R L
出版信息
Br J Cancer. 1985 Jan;51(1):31-6. doi: 10.1038/bjc.1985.5.
The cytostatic activity of a population of cultured syngeneic and allogeneic Kupffer cells against the K31 tumour cell line has been studied in vitro. The addition of purified populations if Kupffer cells to the tumour cell line resulted in a reduction in the uptake of 125IUdR by the tumour cells. This cytostatic activity was not due to a non-labile supernatant effect. There was a progressive loss of the cytostatic activity of the Kupffer cells as their time in culture increased. The experiments show that Kupffer cells, like other macrophages, possess cytostatic activity in vitro which is not genetically restricted.
已在体外研究了一群培养的同基因和异基因库普弗细胞对K31肿瘤细胞系的细胞抑制活性。将纯化的库普弗细胞群体添加到肿瘤细胞系中导致肿瘤细胞对125IUdR的摄取减少。这种细胞抑制活性并非由于不稳定的上清液效应。随着库普弗细胞培养时间的增加，其细胞抑制活性逐渐丧失。实验表明，库普弗细胞与其他巨噬细胞一样，在体外具有不受基因限制的细胞抑制活性。
Zotero 插件