Hogg N, Parish C R
Immunology. 1980 Sep;41(1):187-93.
By rosetting techniques, peritoneal exudate cells (PEC) from mice stimulated intraperitoneally with starch have been shown to be a mixed population of cells consisting of the following subpopulations of cells: 75% FcR, 26% C3R, 18% Ig+, 29% Ia+, Ig- and 5% Thy-1+, Ig-. By separating rosetting from non-rosetting cells, it was possible to establish the phenotype of the PEC which was cytostatic for tumour cells. This cell possessed receptors for Fc and C3 but lacked surface Ig, the Thy-1 antigen and I-region controlled antigens and was NSE positive. Thus by presently available criteria, the cytostatic PEC can be identified as a macrophage. The lack of Ia distinguishes this type of macrophage from the antigen-presenting macrophage which bears Ia.
通过玫瑰花结技术，已证明经腹腔注射淀粉刺激的小鼠腹腔渗出细胞（PEC）是由以下细胞亚群组成的混合细胞群体：75% FcR、26% C3R、18% Ig⁺、29% Ia⁺、Ig⁻和5% Thy-1⁺、Ig⁻。通过将形成玫瑰花结的细胞与未形成玫瑰花结的细胞分离，得以确定对肿瘤细胞具有细胞抑制作用的PEC的表型。这种细胞具有Fc和C3受体，但缺乏表面Ig、Thy-1抗原和I区控制的抗原，且NSE呈阳性。因此，根据目前可用的标准，具有细胞抑制作用的PEC可被鉴定为巨噬细胞。缺乏Ia使这种巨噬细胞类型与带有Ia的抗原呈递巨噬细胞区分开来。
