Talmadge J E, Key M, Fidler I J
J Immunol. 1981 Jun;126(6):2245-8.
In this study, we have examined the macrophage content of 16 different rodent tumors and failed to demonstrate a correlation between the extent of macrophage infiltration into neoplasms and the metastatic behavior of the tumor. We also did not find a correlation between the macrophage content of ultraviolet radiation- (UV) induced murine fibrosarcomas growing in normal or UV-irradiated syngeneic mice and the immunogenic potential of the tumor. After s.c. inoculation of single viable cells, tumors with a high level of infiltrating macrophages required a longer induction period to form palpable tumors than tumors with low macrophage content. The macrophage content of neoplasms also did not correlate with in vitro or in vivo growth rates. We conclude that no generalizations can be drawn regarding the relationship between macrophage content of neoplasms and their metastatic potential.
在本研究中，我们检测了16种不同啮齿动物肿瘤中的巨噬细胞含量，未发现巨噬细胞浸润肿瘤的程度与肿瘤转移行为之间存在相关性。我们也未发现正常或紫外线照射的同基因小鼠体内生长的紫外线诱导的鼠纤维肉瘤的巨噬细胞含量与肿瘤的免疫原性之间存在相关性。皮下接种单个活细胞后，与巨噬细胞含量低的肿瘤相比，巨噬细胞浸润水平高的肿瘤形成可触及肿瘤所需的诱导期更长。肿瘤的巨噬细胞含量也与体外或体内生长速率无关。我们得出结论，关于肿瘤的巨噬细胞含量与其转移潜能之间的关系，无法得出一般性结论。
