Luo Xin, Chen Minghong, Xu Jinghong
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Trauma Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Front Med (Lausanne). 2024 Nov 28;11:1486807. doi: 10.3389/fmed.2024.1486807. eCollection 2024.
Osteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hypoxia and hypercapnia. We hypothesize that these stressors induce aging and increase the prevalence of OA.
The study included 10,641 participants drawn from the National Health and Nutrition Examination Survey (NHANES) dataset during 2005-2008 and 2015-2018. The correlation between OSAS and OA was analyzed using multivariable logistic regression, aging-related biomarkers were calculated, and the role of aging was explored through mediation analysis.
OSAS was associated with an elevated risk of OA (for quartile 4 vs. quartile 1, odds ratio (OR) 2.31, 95% confidence interval (CI) 1.34 to 3.99; -value for the trend = 0.004) after adjusting covariates. In the 20-59 years and > 60 years subgroup, the OSAS patients showed a similar trend (for quartile 4 vs. quartile 1, OR 5.69, 95% CI 2.75 to 11.8; -value for the trend <0.001; OR 2.42, 95% CI 1.23 to 4.76; -value for the trend = 0.004, respectively). Further mediation analysis revealed that aging acted as a mediator between OA and OSAS. The mediation proportions for biological age (BA) and phenotypic age (PA) were 13.82 and 52.94%, respectively, both with < 0.001.
These findings suggest that individuals with OSAS may have an increased prevalence of OA, with aging also being involved in the association.
骨关节炎（OA）具有高发病率和致残率的特点。虽然研究表明OA与年龄相关疾病有关，但很少有研究显示OA与阻塞性睡眠呼吸暂停综合征（OSAS）之间的潜在关系。OSAS的特征是间歇性缺氧和高碳酸血症。我们假设这些应激源会导致衰老并增加OA的患病率。
该研究纳入了2005 - 2008年和2015 - 2018年期间从美国国家健康与营养检查调查（NHANES）数据集中抽取的10641名参与者。使用多变量逻辑回归分析OSAS与OA之间的相关性，计算与衰老相关的生物标志物，并通过中介分析探讨衰老的作用。
调整协变量后，OSAS与OA风险升高相关（四分位数4与四分位数1相比，比值比（OR）为2.31，95%置信区间（CI）为1.34至3.99；趋势P值 = 0.004）。在20 - 59岁和>60岁亚组中，OSAS患者呈现出类似趋势（四分位数4与四分位数1相比，OR分别为5.69，95%CI为2.75至11.8；趋势P值<0.001；OR为2.42，95%CI为1.23至4.76；趋势P值 = 0.004）。进一步的中介分析表明，衰老在OA和OSAS之间起中介作用。生物年龄（BA）和表型年龄（PA）的中介比例分别为13.82%和52.94%，两者P值均<0.001。
这些发现表明，患有OSAS的个体可能有更高的OA患病率，衰老也参与了这种关联。
