Bliss Tim
Group Leader Emeritus, The Francis Crick Institute, London, UK.
Hippocampus. 2025 Jan;35(1):e23665. doi: 10.1002/hipo.23665.
Here I describe how an interest in synaptic plasticity took me from a PhD at McGill, where I worked on activity-dependent plasticity in the responses of single units in the association cortex of anesthetized cats, to a collaboration with Terje Lømo in Per Andersen's laboratory in Oslo in 1968-9. There we followed up on Lømo's discovery of LTP, published as an abstract in 1966, to produce the first detailed description of the phenomenon. Later, in London, Tony Gardner-Medwin and I showed that LTP lasting for days could be obtained in the awake rabbit. The two papers were published together in the Journal of Physiology in 1973. I relate how difficulties in replicating our results in English rabbits, and the failure of the first attempts to obtain LTP in slices of the dentate gyrus, led to my abandoning work on LTP for a few years, returning to the fray in the late 1970s through a collaboration with Graham Goddard at Dalhousie University in Halifax, Canada.
在这里，我将讲述对突触可塑性的兴趣是如何引领我从在麦吉尔大学攻读博士学位开始的。在麦吉尔大学时，我研究麻醉猫联合皮层中单个神经元活动依赖的可塑性。之后，在1968年至1969年期间，我与特耶·勒莫在奥斯陆的佩尔·安德森实验室展开合作。在那里，我们对勒莫于1966年以摘要形式发表的长时程增强（LTP）的发现进行了跟进，从而首次对该现象进行了详细描述。后来在伦敦，我和托尼·加德纳 - 梅德温证明在清醒的兔子身上可以获得持续数天的LTP。这两篇论文于1973年共同发表在《生理学杂志》上。我还会讲述在英国兔子身上复制我们的结果时遇到的困难，以及首次尝试在齿状回切片中获得LTP的失败，这导致我放弃了对LTP的研究数年，直到20世纪70年代末通过与加拿大哈利法克斯达尔豪斯大学的格雷厄姆·戈达德合作才重新回到这一领域进行研究工作。
