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Super-resolution left ventricular flow and pressure mapping by Navier-Stokes-informed neural networks.

作者信息

Maidu Bahetihazi, Martinez-Legazpi Pablo, Guerrero-Hurtado Manuel, Nguyen Cathleen M, Gonzalo Alejandro, Kahn Andrew M, Bermejo Javier, Flores Oscar, Del Alamo Juan C

机构信息

Dept. of Mechanical Engineering, University of Washington, Seattle, WA, USA.

Dept. of Mathematical Physics and Fluids. Universidad Nacional de Educación a Distancia & CIBERCV, Madrid, Spain.

出版信息

Comput Biol Med. 2025 Feb;185:109476. doi: 10.1016/j.compbiomed.2024.109476. Epub 2024 Dec 12.


DOI:10.1016/j.compbiomed.2024.109476
PMID:39672010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11798758/
Abstract

Intraventricular vector flow mapping (VFM) is an increasingly adopted echocardiographic technique that derives time-resolved two-dimensional flow maps in the left ventricle (LV) from color-Doppler sequences. Current VFM models rely on kinematic constraints arising from planar flow incompressibility. However, these models are not informed by crucial information about flow physics; most notably the forces within the fluid and the resulting accelerations. This limitation has rendered VFM unable to combine information from different time frames in an acquisition sequence or derive fluctuating pressure maps. In this study, we leveraged recent advances in artificial intelligence (AI) to develop AI-VFM, a vector flow mapping modality that uses physics-informed neural networks (PINNs) encoding mass conservation and momentum balance inside the LV, and no-slip boundary conditions at the LV endocardium. AI-VFM recovers the flow and pressure fields in the LV from standard echocardiographic scans. It performs phase unwrapping and recovers flow data in areas without input color-Doppler data. AI-VFM also recovers complete flow maps at time points without color-Doppler input data, producing super-resolution flow maps. We validate AI-VFM using physiological simulated LV data and show that informing the PINNs with momentum balance is essential for achieving temporal super-resolution and significantly increases the accuracy of AI-VFM compared to informing the PINNs only with mass conservation. AI-VFM is solely informed by each patient's flow physics; it does not utilize explicit smoothness constraints or incorporate data from other patients or flow models. AI-VFM takes 15 min to run in off-the-shelf graphics processing units and its underlying PINN framework could be extended to map other flow-associated metrics such as blood residence time or the concentration of coagulation species.

摘要

相似文献

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[2]
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引用本文的文献

[1]
Physics-informed neural networks for physiological signal processing and modeling: a narrative review.

Physiol Meas. 2025-7-30

本文引用的文献

[1]
Physics-Guided Neural Networks for Intraventricular Vector Flow Mapping.

IEEE Trans Ultrason Ferroelectr Freq Control. 2024-11

[2]
On the importance of fundamental computational fluid dynamics toward a robust and reliable model of left atrial flows.

Int J Numer Method Biomed Eng. 2024-4

[3]
Efficient multi-fidelity computation of blood coagulation under flow.

PLoS Comput Biol. 2023-10

[4]
Machine Learning and the Conundrum of Stroke Risk Prediction.

Arrhythm Electrophysiol Rev. 2023-4-12

[5]
A comparison of phase unwrapping methods in velocity-encoded MRI for aortic flows.

Magn Reson Med. 2023-11

[6]
Full-volume three-component intraventricular vector flow mapping by triplane color Doppler.

Phys Med Biol. 2022-4-19

[7]
Non-Newtonian blood rheology impacts left atrial stasis in patient-specific simulations.

Int J Numer Method Biomed Eng. 2022-6

[8]
EP-PINNs: Cardiac Electrophysiology Characterisation Using Physics-Informed Neural Networks.

Front Cardiovasc Med. 2022-2-3

[9]
WSSNet: Aortic Wall Shear Stress Estimation Using Deep Learning on 4D Flow MRI.

Front Cardiovasc Med. 2022-1-24

[10]
Learning atrial fiber orientations and conductivity tensors from intracardiac maps using physics-informed neural networks.

Funct Imaging Model Heart. 2021-6-18

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