Hecht F, Berger C S, Sandberg A A
Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):197-203. doi: 10.1016/0165-4608(85)90185-2.
Chromosome studies were done on an adenocarcinoma of the kidney and a transitional cell carcinoma of the kidney. The adenocarcinoma was in the renal parenchyma, whereas the transitional cell carcinoma was in the kidney pelvis. The adenocarcinoma was moderately well differentiated, and the transitional cell tumor was poorly differentiated. The adenocarcinoma was hypotetraploid, with 69-75 chromosomes per cell, and the transitional cell carcinoma was pseudodiploid, with 46 chromosomes. Both tumors showed a nonreciprocal t(5;14) translocation that resulted in a 5q- and a 14q+ chromosome with loss of 14q material. The breakpoints were in bands 5q13 and 14q22. Both tumors also contained an extra 5q- chromosome. The oncogene c-fms is normally situated in band 5q34 and so may have been translocated onto 14q, although whether it has been activated is conjectural. The t(5;14) translocation may be another tissue-specific cancer chromosome change.
对一例肾腺癌和一例肾移行细胞癌进行了染色体研究。腺癌位于肾实质，而移行细胞癌位于肾盂。腺癌为中度分化良好，移行细胞瘤为低分化。腺癌为亚四倍体，每个细胞有69 - 75条染色体，移行细胞癌为假二倍体，有46条染色体。两种肿瘤均显示非相互性t(5;14)易位，导致一条5号染色体长臂缺失（5q-）和一条14号染色体长臂增加（14q+），伴有14号染色体长臂物质丢失。断点位于5q13和14q22带。两种肿瘤还都含有一条额外的5号染色体长臂缺失（5q-）染色体。癌基因c-fms通常位于5q34带，因此可能已易位到14号染色体长臂上，尽管其是否已被激活尚属推测。t(5;14)易位可能是另一种组织特异性的癌症染色体改变。
