de Jong B, Oosterhuis J W, Idenburg V J, Castedo S M, Dam A, Mensink H J
Department of Human Genetics, State University, Groningen, The Netherlands.
Cancer Genet Cytogenet. 1988 Jan;30(1):53-61. doi: 10.1016/0165-4608(88)90092-1.
The cytogenetics of 12 cases of renal adenocarcinoma are presented. Clonal abnormalities were found in nine patients. Worth mentioning are abnormalities of the X chromosome (1 X) and the chromosomes #1(3 X), #3(3 X), #7(4 X), #8(4 X), and #14(2 X). From our data and data from the literature it appeared that the chromosomal regions 3p11-p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.
本文报告了12例肾腺癌的细胞遗传学情况。在9例患者中发现了克隆性异常。值得一提的是X染色体（1例）以及1号染色体（3例）、3号染色体（3例）、7号染色体（4例）、8号染色体（4例）和14号染色体（2例）的异常。从我们的数据以及文献数据来看，染色体区域3p11 - p21、1q21、14q22和Xp11对于肾细胞癌的肿瘤发生以及7号染色体剂量增加、8号和14号染色体缺失或异常而言都很重要。
