美法仑治疗后出现12号染色体短臂缺失和19号染色体长臂增加的白血病前期和白血病
Preleukemia and leukemia with 12p- and 19q+ chromosome alterations following Alkeran therapy.
作者信息
Wilmoth D, Feder M, Finan J, Nowell P
出版信息
Cancer Genet Cytogenet. 1985 Feb 1;15(1-2):95-8. doi: 10.1016/0165-4608(85)90135-9.
PMID:3967221
Abstract
Among 20 patients with acute nonlymphocytic leukemia or dysmyelopoietic preleukemia secondary to Alkeran therapy for another tumor, four had a del(12)(p11-p12) and four had a translocation to 19q13 among multiple karyotypic alterations in their neoplastic hematopoetic clones. It is suggested that these two cytogenetic abnormalities may occur nonrandomly in such hemic disorders and may play a limited role in their pathogenesis.
摘要
在20例因曾接受美法仑治疗其他肿瘤继发急性非淋巴细胞白血病或骨髓增生异常前期白血病的患者中，4例存在del(12)(p11-p12)，4例在其肿瘤性造血克隆的多种核型改变中有19q13易位。提示这两种细胞遗传学异常可能在这类血液系统疾病中并非随机出现，且可能在其发病机制中起有限作用。
Zotero 插件